青海医学院学报
青海醫學院學報
청해의학원학보
JOURNAL OF QINGHAI MEDICAL COLLEGE
2014年
3期
153-159
,共7页
杨应忠%王亚平%胥瑾%赵艳霞%马兰%格日力
楊應忠%王亞平%胥瑾%趙豔霞%馬蘭%格日力
양응충%왕아평%서근%조염하%마란%격일력
HAPE%EGLN1%单核苷酸多态性
HAPE%EGLN1%單覈苷痠多態性
HAPE%EGLN1%단핵감산다태성
目的 探讨rs10932688、rs12655827、rs2017869、rs4572038、rs4984295、rs11581271、rs17052028、rs3009568、rs4906864多态性位点与HAPE相关关系.方法 采用病例对照研究,选取汉族HAPE患者135例,汉族健康对照者137例.采用改良多重高温连接酶检测法检测rs10932688、rs12655827、rs2017869、rs4572038、rs4984295、rs11581271、rs17052028、rs3009568、rs4906864单核苷酸位点的多态性并行相关分析.结果 rs10932688、rs12655827、rs2017869、rs4572038、rs4984295、rs11581271、rs17052028、rs3009568的基因型频率在HAPE组和对照组之间差异均无统计学意义.rs4906864的基因型TT在HAPE组(14.8％)和对照组(0.08％)间差异有显著性(P＜0.05),odds ratio为0.425(0.187 ～ 0.966);等位基因T在HAPE组(38.5％)和对照组(29.9％)间差异有显著性(P＜0.05),odds ratio为0.682 (0.477 ～0.973).结论 rs4906864的基因型TF和等位基因T在HAPE组和对照组间差异有显著性,可能与HAPE病理生理过程相关.
目的 探討rs10932688、rs12655827、rs2017869、rs4572038、rs4984295、rs11581271、rs17052028、rs3009568、rs4906864多態性位點與HAPE相關關繫.方法 採用病例對照研究,選取漢族HAPE患者135例,漢族健康對照者137例.採用改良多重高溫連接酶檢測法檢測rs10932688、rs12655827、rs2017869、rs4572038、rs4984295、rs11581271、rs17052028、rs3009568、rs4906864單覈苷痠位點的多態性併行相關分析.結果 rs10932688、rs12655827、rs2017869、rs4572038、rs4984295、rs11581271、rs17052028、rs3009568的基因型頻率在HAPE組和對照組之間差異均無統計學意義.rs4906864的基因型TT在HAPE組(14.8％)和對照組(0.08％)間差異有顯著性(P＜0.05),odds ratio為0.425(0.187 ～ 0.966);等位基因T在HAPE組(38.5％)和對照組(29.9％)間差異有顯著性(P＜0.05),odds ratio為0.682 (0.477 ～0.973).結論 rs4906864的基因型TF和等位基因T在HAPE組和對照組間差異有顯著性,可能與HAPE病理生理過程相關.
목적 탐토rs10932688、rs12655827、rs2017869、rs4572038、rs4984295、rs11581271、rs17052028、rs3009568、rs4906864다태성위점여HAPE상관관계.방법 채용병례대조연구,선취한족HAPE환자135례,한족건강대조자137례.채용개량다중고온련접매검측법검측rs10932688、rs12655827、rs2017869、rs4572038、rs4984295、rs11581271、rs17052028、rs3009568、rs4906864단핵감산위점적다태성병행상관분석.결과 rs10932688、rs12655827、rs2017869、rs4572038、rs4984295、rs11581271、rs17052028、rs3009568적기인형빈솔재HAPE조화대조조지간차이균무통계학의의.rs4906864적기인형TT재HAPE조(14.8％)화대조조(0.08％)간차이유현저성(P＜0.05),odds ratio위0.425(0.187 ～ 0.966);등위기인T재HAPE조(38.5％)화대조조(29.9％)간차이유현저성(P＜0.05),odds ratio위0.682 (0.477 ～0.973).결론 rs4906864적기인형TF화등위기인T재HAPE조화대조조간차이유현저성,가능여HAPE병리생리과정상관.
