中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
28期
16-18
,共3页
糖抗原CA19-9%糖尿病酮症酸中毒
糖抗原CA19-9%糖尿病酮癥痠中毒
당항원CA19-9%당뇨병동증산중독
Carbohydrate antigen 19-9%Diabetic ketoacidosis
目的：回顾性观察糖尿病酮症酸中毒患者血清CA19-9水平，分析糖尿病急性代谢紊乱状态下CA19-9升高的特点。方法：选取糖尿病酮症酸中毒患者73例和血糖控制差（糖化大于7.5%）的糖尿病非酮症酸中毒患者209例，对其性别、年龄、糖尿病病程、体重指数、HbA1c、CA19-9水平进行分析。结果：（1）酮症酸中毒组平均CA19-9水平29.7（57.8~15.35）U/mL，显著高于非酮症酸中毒组10.1（19.65~5.40）U/mL，比较差异有统计学意义（P<0.01）；前者CA19-9升高的比例为39.7%，而后者为7.7%（P<0.01），两者比较差异有统计学意义。（2）CA19-9升高的45例患者中数值在200 U/mL以内者占95.6%，其中10例患者病情纠正后复查CA19-9均呈下降趋势。结论：糖尿病患者CA19-9水平在酮症酸中毒状态下较非酮症酸中毒状态下可更明显升高。
目的：迴顧性觀察糖尿病酮癥痠中毒患者血清CA19-9水平，分析糖尿病急性代謝紊亂狀態下CA19-9升高的特點。方法：選取糖尿病酮癥痠中毒患者73例和血糖控製差（糖化大于7.5%）的糖尿病非酮癥痠中毒患者209例，對其性彆、年齡、糖尿病病程、體重指數、HbA1c、CA19-9水平進行分析。結果：（1）酮癥痠中毒組平均CA19-9水平29.7（57.8~15.35）U/mL，顯著高于非酮癥痠中毒組10.1（19.65~5.40）U/mL，比較差異有統計學意義（P<0.01）；前者CA19-9升高的比例為39.7%，而後者為7.7%（P<0.01），兩者比較差異有統計學意義。（2）CA19-9升高的45例患者中數值在200 U/mL以內者佔95.6%，其中10例患者病情糾正後複查CA19-9均呈下降趨勢。結論：糖尿病患者CA19-9水平在酮癥痠中毒狀態下較非酮癥痠中毒狀態下可更明顯升高。
목적：회고성관찰당뇨병동증산중독환자혈청CA19-9수평，분석당뇨병급성대사문란상태하CA19-9승고적특점。방법：선취당뇨병동증산중독환자73례화혈당공제차（당화대우7.5%）적당뇨병비동증산중독환자209례，대기성별、년령、당뇨병병정、체중지수、HbA1c、CA19-9수평진행분석。결과：（1）동증산중독조평균CA19-9수평29.7（57.8~15.35）U/mL，현저고우비동증산중독조10.1（19.65~5.40）U/mL，비교차이유통계학의의（P<0.01）；전자CA19-9승고적비례위39.7%，이후자위7.7%（P<0.01），량자비교차이유통계학의의。（2）CA19-9승고적45례환자중수치재200 U/mL이내자점95.6%，기중10례환자병정규정후복사CA19-9균정하강추세。결론：당뇨병환자CA19-9수평재동증산중독상태하교비동증산중독상태하가경명현승고。
Objective:To retrospectively observe the alteration of serum CA19-9 levels in patients with diabetic ketoacidosis(DKA)compared to diabetics without DKA. Method:Seventy-three patients with DKA(DKA group)and 209 diabetics under dissatisfied glucose control(non-DKA group,HbA1c>7.5%)were enrolled. Records of gender,age, diabetic duration,BMI,HbA1c,CA19-9 level were collected. The levels of serum CA19-9 were compared between the two groups. Result:(1)Average CA19-9 level was significantly higher in DKA group 29.7(57.8-15.35)U/mL than that in non-DKA group 10.1(19.65-5.40)U/mL(P<0.01),as well as the percentage of positive CA19-9 level(39.7%and 7.7%,P<0.01).(2)The abnormal values were in range of 37.1-674.5 U/mL,mainly distributed within 200 U/mL(95.6%). Conclusion:Slight to moderate elevations of CA19-9 levels are more frequently found in DKA patients than diabetics under poor glucose control,as well as significant higher levels.
