CAJ | 학술논문

[目的]观察1.25%碳酸氢钠雾化吸入对慢性阻塞性肺疾病(COPD)急性加重期病人排痰的辅助疗效。[方法]将83例 COPD急性加重期病人随机分为观察组(42例)和对照组(41例)。在常规内科治疗基础上对照组采用复方异丙托溴胺和氨溴索雾化，观察组在对照组基础上加用1.25%碳酸氢钠溶液雾化。比较两组病人治疗后第1天、第3天、第7天24 h 排痰量、1周后肺功能情况、肺部啰音消失时间、体温恢复正常时间、血常规恢复正常时间以及住院时间。[结果]观察组病人第3天排痰量明显多于对照组(P<0.01)；观察组病人住院1周后肺功能检测明显好于对照组(P<0.05或 P<0.01)；观察组病人临床症状控制所需时间、体温恢复正常所需时间、血常规正常所需时间以及住院时间较对照组明显缩短。[结论]碳酸氢钠联合异丙托溴胺、氨溴索雾化吸入可提高COPD病人气道湿化排痰效果，提高临床疗效，缩短病人住院时间。
[목적]관찰1.25%탄산경납무화흡입대만성조새성폐질병(COPD)급성가중기병인배담적보조료효。[방법]장83례 COPD급성가중기병인수궤분위관찰조(42례)화대조조(41례)。재상규내과치료기출상대조조채용복방이병탁추알화안추색무화，관찰조재대조조기출상가용1.25%탄산경납용액무화。비교량조병인치료후제1천、제3천、제7천24 h 배담량、1주후폐공능정황、폐부라음소실시간、체온회복정상시간、혈상규회복정상시간이급주원시간。[결과]관찰조병인제3천배담량명현다우대조조(P<0.01)；관찰조병인주원1주후폐공능검측명현호우대조조(P<0.05혹 P<0.01)；관찰조병인림상증상공제소수시간、체온회복정상소수시간、혈상규정상소수시간이급주원시간교대조조명현축단。[결론]탄산경납연합이병탁추알、안추색무화흡입가제고COPD병인기도습화배담효과，제고림상료효，축단병인주원시간。
Objective:To observe the secondary effect of 1.25% sodium bi-carbonate aerosol inhalation on sputum exclusion in patients with chronic obstructive pulmonary disease (COPD)in acute exacerbation.Methods:A total of 83 cases of patients with acute exacerbation of COPD were random-ly divided into observation group (42 cases)and control group (41 cases). Patients in control group used compound ipratropium bromide solution and ambroxol inhalation based on conventional medical treatment;the patients in observation group received 1.25% sodium bicarbonate solution atomiza-tion on the basis of control group's treatment.The 24 h sputum volume was compared between both groups on the first day,the first three days,the first 7 days after treatment,lung function after one week,pulmonary rales re-duced and disappeared time,temperature returned to normal time,routine blood test recovery time and hospital time.Results:The sputum volume of patients in observation group on the first three days was more than that in control group significantly (P<0.01);lung function of patients in observa-tion group after hospitalized one week was significantly better than that in control group (P<0.05 or P<0.01);control group of patients with clinical symptoms control required time,the required time to body temperature re-store normal,blood normal required time and the length of hospital stay were significantly shorter than those in control group (P<0.05).Conclu-sion:Sodium bicarbonate combined with compound Ipratropium Bromide solution and Ambroxol atomizing inhalation can dilute sputum,improve the effect of sputum exclusion,improve lung function and shorten hospitaliza-tion time of COPD patients.