CAJ | 학술논문

目的：观察加味温胆汤联合尼莫地平片治疗非痴呆型血管性认知功能障碍(VCIND)痰瘀阻络型患者的临床效果。方法将89例VCIND痰瘀阻络型患者随机分为中医治疗组29例、西医治疗组30例和中西医治疗组30例。中医治疗组以温胆汤加味，西医治疗组口服尼莫地平片，中西医治疗组以加味温胆汤和西药尼莫地平为主，3组均以10周为1个疗程。治疗前后采用日常生活活动能力(ADL)评定量表、蒙特利尔认知评估量表(MoCA)进行评分。结果3组治疗后ADL及MoCA评分均高于治疗前，差异有统计学意义(P<0.05)；且中西医治疗组评分高于中医治疗组及西医治疗组(P<0.05)。治疗期间，3组未出现明显的不良反应。结论加味温胆汤联合尼莫地平片治疗VCIND痰瘀阻络型患者安全有效。
목적：관찰가미온담탕연합니막지평편치료비치태형혈관성인지공능장애(VCIND)담어조락형환자적림상효과。방법장89례VCIND담어조락형환자수궤분위중의치료조29례、서의치료조30례화중서의치료조30례。중의치료조이온담탕가미，서의치료조구복니막지평편，중서의치료조이가미온담탕화서약니막지평위주，3조균이10주위1개료정。치료전후채용일상생활활동능력(ADL)평정량표、몽특리이인지평고량표(MoCA)진행평분。결과3조치료후ADL급MoCA평분균고우치료전，차이유통계학의의(P<0.05)；차중서의치료조평분고우중의치료조급서의치료조(P<0.05)。치료기간，3조미출현명현적불량반응。결론가미온담탕연합니막지평편치료VCIND담어조락형환자안전유효。
Objective To observe the clinical effect of Jiawei Wendantang combined with nimodipine in the treatment of vascular cognitive impairment no dementia (VCIND). Methods 89 cases of patients with blood stasis and phlegm stagnancy of VCIND were selected and randomly divided into group of TCM (29 cases),western medicine group (30 cas-es),and TCM combined with western medicine group (30 cases).Group of TCM was treated by Jiawei Wendantang,west-ern medicine group was treated by nimodipine,and TCM combined with western medicine group was treated by Jiawei Wendantang combined with nimodipine.Three groups were received treatment for ten weeks of one course.Activities of daily living (ADL) and Montreal cognitive assessment (MoCA) were evaluated before and after treatment. Results ADL and MoCA score of three groups after treatment were increased compared with before treatment (P<0.05);and the score of TCM combined with western medicine group was better than that of group of TCM and western medicine group (P<0.05).During treatment,the three groups had no significant adverse reactions. Conclusion Jiawei Wendantang combined with nimodipine in the treatment of VCIND is safe and effective.