CAJ | 학술논문

目的：探讨重组人促血小板生成素(rhTPO)治疗急性白血病化疗后血小板减少的临床效果。方法选取2012年1月~2014年1月在本院接受化疗治疗且发生血小板减少症的急性白血病患者56例，将其随机分为观察组和对照组，每组各28例。观察组给予rhTPO治疗，对照组给予重组人白介素-11(rhIL-11)治疗，比较两组的疗效。结果观察组治疗后的血小板水平明显高于对照组，且血小板<50×109/L的持续时间、恢复至70×109/L和100×109/L所需时间明显短于对照组(P<0.05)；观察组的不良反应发生率明显低于对照组(3.6% vs 42.8%)(P<0.05)。结论 rhTPO治疗急性白血病化疗后血小板减少的效果显著，安全性高，值得临床推广应用。
목적：탐토중조인촉혈소판생성소(rhTPO)치료급성백혈병화료후혈소판감소적림상효과。방법선취2012년1월~2014년1월재본원접수화료치료차발생혈소판감소증적급성백혈병환자56례，장기수궤분위관찰조화대조조，매조각28례。관찰조급여rhTPO치료，대조조급여중조인백개소-11(rhIL-11)치료，비교량조적료효。결과관찰조치료후적혈소판수평명현고우대조조，차혈소판<50×109/L적지속시간、회복지70×109/L화100×109/L소수시간명현단우대조조(P<0.05)；관찰조적불량반응발생솔명현저우대조조(3.6% vs 42.8%)(P<0.05)。결론 rhTPO치료급성백혈병화료후혈소판감소적효과현저，안전성고，치득림상추엄응용。
Objective To investigate the clinical effect of recombinant human thrombopoietin (rhTPO) in the treatment of thrombocytopenia caused by chemotherapy of acute leukemia. Methods Fifty-six patients who received chemothera-py and suffered from thrombocytopenia due to it in our hospital were selected and randomly divided into the observa-tion group (n=28) and the control group (n=28).The observation group received rhTPO treatment and the control group received recombinant human interleukin-11 (rhIL-11) treatment.The efficacy of the two groups was compared. Results After treatment,the platelet level in the observation group was significantly higher than that in the control group,and duration of platelets<50í109/L and time of platelet returning to 70í109/L and 100í109/L in the observation group were significantly shorter than those in the control group (P<0.05).The incidence rate in the the observation group was obvi-ously lower than that in the control group (3.6% vs 42.8%) (P<0.05). Conclusion In the treatment of thrombocytopenia caused by chemotherapy of acute leukemia,rhTPO shows remarkable effects and high safety,thereby it is worthy of clin-ical promotion and application.