CAJ | 학술논문

目的：从剂量学探讨减小非小细胞肺癌三维适形放射治疗照射体积的可行性。方法32例非小细胞肺癌患者均做2个放射治疗计划：常规照射野三维适形放射治疗计划和小野三维适形放射治疗计划，用剂量体积直方图评估肿瘤靶区剂量和正常组织受照剂量。结果小野三维适形放射治疗仍能满足肿瘤靶区剂量的要求，亚临床灶的最小剂量、最大剂量和平均剂量分别为50．93 Gy、54．60 Gy和（52．37±1．02）Gy。与常规适形野相比，小野适形放疗减少了患侧肺、脊髓和食管的平均剂量（P＜0．05）。结论缩小非小细胞肺癌三维适形放射治疗照射野能满足肿瘤靶区剂量的需要，同时降低了正常组织的受照剂量，可在临床开展相关研究。
목적：종제량학탐토감소비소세포폐암삼유괄형방사치료조사체적적가행성。방법32례비소세포폐암환자균주2개방사치료계화：상규조사야삼유괄형방사치료계화화소야삼유괄형방사치료계화，용제량체적직방도평고종류파구제량화정상조직수조제량。결과소야삼유괄형방사치료잉능만족종류파구제량적요구，아림상조적최소제량、최대제량화평균제량분별위50．93 Gy、54．60 Gy화（52．37±1．02）Gy。여상규괄형야상비，소야괄형방료감소료환측폐、척수화식관적평균제량（P＜0．05）。결론축소비소세포폐암삼유괄형방사치료조사야능만족종류파구제량적수요，동시강저료정상조직적수조제량，가재림상개전상관연구。
Objective To investigate the dosimetry and feasibility of target volume reduction in three-dimensional conformal radiotherapy for non-small cell lung cancer(NSCLC).Methods Two differ-ent radiation treatment planning,the conventional conformal planning and the small volume conformal plan-ning,were designed for 32 NSCLC patients.Dose-olume histograms were used to assess the dosimetric dis-parity in target regions and surrounding organs at risk.Results Small volume conformal planning could meet the demand of target dose.The least dose,the maximum dose,and the mean dose at subclinical targets were 50.93 Gy,54.60 Gy and(52.37 ±1.02)Gy,respectively.Comparing with the conventional conformal planning,small volume conformal planning reduced the mean dose of lung,spinal cord and esophagus(P<0.05).Conclusion Small volume conformal planning can meet the dosimetric requirement of target vol-ume for NSCLC and reduce the dose of normal tissues,which is worthy of further clinical study.