CAJ | 학술논문

抗生素的出现阻碍了致病菌的传播，但随着抗生素的广泛使用，细菌的耐药性问题越来越严重，给临床治疗带来巨大困难。细菌对β-内酰胺类抗生素的耐药问题已经引起广泛重视。致病菌能够在动物机体内定植、入侵并破坏机体的免疫系统，最终引起动物的发病，往往与其含有的毒力因子有关。近年来，随着研究的不断深入，人们发现细菌毒力的变化与其耐药性之间存在一定的关系。论文主要针对细菌的β-内酰胺类抗生素耐药和毒力之间的关系进行综述。
항생소적출현조애료치병균적전파，단수착항생소적엄범사용，세균적내약성문제월래월엄중，급림상치료대래거대곤난。세균대β-내선알류항생소적내약문제이경인기엄범중시。치병균능구재동물궤체내정식、입침병파배궤체적면역계통，최종인기동물적발병，왕왕여기함유적독력인자유관。근년래，수착연구적불단심입，인문발현세균독력적변화여기내약성지간존재일정적관계。논문주요침대세균적β-내선알류항생소내약화독력지간적관계진행종술。
Antibiotics is essential in controlling infection caused by bacteria,unfortunately,the resistance of bacteria has emerged because of its extensive use,especially in beta-lactam antibiotics,which lead to a significant clinical problem worldwide in treating infections caused by bacteria.Virulence factors play a cru-cial role in its pathogenicity,particularly in permanent planting and invasion of the immune system in ani-mals.The recent studies indicated that there was a link between virulence factors and antibiotic resistance in bacteria.In this paper,the connection between virulence factors and beta-lactam antibiotic resistance were discussed.