CAJ | 학술논문

对于许多病毒而言，一种或两种蛋白就可以完成病毒与宿主细胞的结合，膜融合以及入侵等生物过程。然而，痘病毒却需要利用许多种蛋白完成这一生物过程，这可能与其能感染多种细胞有关联。已鉴定的9种入侵融合复合体蛋白和2种入侵融合复合体相关蛋白都属于非糖基化的跨膜蛋白，这些蛋白的大小在4 ku～43 ku之间，并且它们之间相互作用可以形成入侵融合复合体（EFC）。这些蛋白在痘病毒中都十分的保守，并且拥有一些共同的性质，这使得它们拥有相似的入侵机制。论文就已鉴定的痘苗病毒的11种入侵融合复合体蛋白的性质、结构、作用以及相互关系做了综述，另外还对可能的入侵融合复合体蛋白进行预测，为痘病毒入侵宿主的机理提供参考。
대우허다병독이언，일충혹량충단백취가이완성병독여숙주세포적결합，막융합이급입침등생물과정。연이，두병독각수요이용허다충단백완성저일생물과정，저가능여기능감염다충세포유관련。이감정적9충입침융합복합체단백화2충입침융합복합체상관단백도속우비당기화적과막단백，저사단백적대소재4 ku～43 ku지간，병차타문지간상호작용가이형성입침융합복합체（EFC）。저사단백재두병독중도십분적보수，병차옹유일사공동적성질，저사득타문옹유상사적입침궤제。논문취이감정적두묘병독적11충입침융합복합체단백적성질、결구、작용이급상호관계주료종술，령외환대가능적입침융합복합체단백진행예측，위두병독입침숙주적궤리제공삼고。
For many viruses,one or two proteins can complete cell binding,membrane fusion and entry. However,vaccinia viruses require a large number of proteins to accomplish these bioprocess.It may be re-lated to its ability to infect a wide range of cells.There are nine EFC proteins and two EFC-associated pro-teins which belong to non-glycosylated,transmembrane proteins in poxvirus.Proteins ranging in size from 4 to 43 ku can associate in a complex.These proteins are conserved in poxvirus and have some common characters and common entry mechanisms.This article summarized the characteristics,structure,role and corelation of the entry fusion complex in vaccinia virus,then predicted the candidate of the components of the EFC.This article provided a theoretical basis for the researches of viral invasion in poxviruses.