国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
15期
1152-1154
,共3页
重度慢性阻塞性肺疾病%氨茶碱%布地奈德
重度慢性阻塞性肺疾病%氨茶堿%佈地奈德
중도만성조새성폐질병%안다감%포지내덕
Severe chronic obstructive pulmonary disease%Aminophylline%Budesonide
目的：探讨小剂量氨茶碱联合布地奈德在治疗重度 COPD 患者的临床效果。方法入选2013年112月我院收治的48例重度 COPD 患者,根据治疗方案不同分为观察组与对照组,各24例。观察组给予小剂量氨茶碱联合布地奈德,对照组仅给予布地奈德。观察两组患者治疗有效率及运动耐量的变化。结果观察组治疗有效率为91.67%,高于对照组的62.50%,差异有统计学意义(P <0.05)；运动耐量检测采用6分钟步行距离(6MWD),治疗前两组6MWD、MRC 比较,差异无统计学意义(P >0.05),治疗后,观察组6MWD 为(345.97±20.35)m,明显高于对照组的(304.99±18.32)m,差异有统计学意义(P <0.05)。治疗后,观察组 MRC 得分(3.56±0.58),明显高于对照组(4.11±0.65),差异有统计学意义(P <0.05)。结论小剂量氨茶碱联合布地奈德在治疗重度 COPD 患者中具有较好的临床疗效,并能够有效提高患者运动耐量,提升生活质量,值得临床推广。
目的：探討小劑量氨茶堿聯閤佈地奈德在治療重度 COPD 患者的臨床效果。方法入選2013年112月我院收治的48例重度 COPD 患者,根據治療方案不同分為觀察組與對照組,各24例。觀察組給予小劑量氨茶堿聯閤佈地奈德,對照組僅給予佈地奈德。觀察兩組患者治療有效率及運動耐量的變化。結果觀察組治療有效率為91.67%,高于對照組的62.50%,差異有統計學意義(P <0.05)；運動耐量檢測採用6分鐘步行距離(6MWD),治療前兩組6MWD、MRC 比較,差異無統計學意義(P >0.05),治療後,觀察組6MWD 為(345.97±20.35)m,明顯高于對照組的(304.99±18.32)m,差異有統計學意義(P <0.05)。治療後,觀察組 MRC 得分(3.56±0.58),明顯高于對照組(4.11±0.65),差異有統計學意義(P <0.05)。結論小劑量氨茶堿聯閤佈地奈德在治療重度 COPD 患者中具有較好的臨床療效,併能夠有效提高患者運動耐量,提升生活質量,值得臨床推廣。
목적：탐토소제량안다감연합포지내덕재치료중도 COPD 환자적림상효과。방법입선2013년112월아원수치적48례중도 COPD 환자,근거치료방안불동분위관찰조여대조조,각24례。관찰조급여소제량안다감연합포지내덕,대조조부급여포지내덕。관찰량조환자치료유효솔급운동내량적변화。결과관찰조치료유효솔위91.67%,고우대조조적62.50%,차이유통계학의의(P <0.05)；운동내량검측채용6분종보행거리(6MWD),치료전량조6MWD、MRC 비교,차이무통계학의의(P >0.05),치료후,관찰조6MWD 위(345.97±20.35)m,명현고우대조조적(304.99±18.32)m,차이유통계학의의(P <0.05)。치료후,관찰조 MRC 득분(3.56±0.58),명현고우대조조(4.11±0.65),차이유통계학의의(P <0.05)。결론소제량안다감연합포지내덕재치료중도 COPD 환자중구유교호적림상료효,병능구유효제고환자운동내량,제승생활질량,치득림상추엄。
Objective To explore the clinical effects of small dose aminophylline combined with budesonide in the treatment of severe chronic obstructive pulmonary disease (COPD)patients.Methods Forty-eight cases of severe COPD patients were treated from January 2013 to December 2013 in our hospital,according to the different treatment schemes were divided into observation group and control group,24 cases in each group.The observation group was given small dose aminophylline and budesonide, while the control group was treated with budesonide.To observe the change of the effective rate and exercise tolerance in patients of the two groups.Results The effective rate of treatment group was 91.67%,higher than 62.50% of the control group was,there was significant difference (P < 0.05 ). Exercise tolerance test by 6 minutes walk distance (6MWD),two groups of 6MWD had no significant difference (P > 0.05 ) before treatment and after treatment,6MWD of the observation group was (345.97±20.35)m after treatment,significantly higher than (304.99 ±18.32)m of the control group, there was significant difference (P < 0.05 ).After treatment,MRC score in the observation group was (3.56±0.58),was significantly higher than that in control group (4.1 1 ± 0.65 ),there was significant difference (P <0.05).Conclusions Small dose aminophylline budesonide has a good clinical efficacy in the treatment of patients with severe COPD,and can effectively improve the exercise tolerance in patients, improve the quality of life,and is worthy of clinical application.
