现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
16期
2436-2437
,共2页
糖尿病,2型/药物疗法%阿卡波糖%治疗结果
糖尿病,2型/藥物療法%阿卡波糖%治療結果
당뇨병,2형/약물요법%아잡파당%치료결과
Diabetes mellitus,type 2/drug therapy%Acarbose%Treatment outcome
目的：探讨口服葡萄糖苷酶抑制剂阿卡波糖治疗2型糖尿病的临床效果，为2型糖尿病患者的用药治疗提供依据。方法选取2011年7月至2013年7月在该院住院的2型糖尿病患者80例，首次给予口服阿卡波糖75~150 mg，以后根据血糖水平进行个体化调整剂量，口服治疗3个月后，观察患者空腹、餐后2小时血糖及糖化血红蛋白的变化，以及治疗前后的血脂、体质量变化，并观察患者的不良反应。结果治疗3个月后，80例患者空腹、餐后2小时血糖以及糖化血红蛋白明显下降，治疗后的血脂明显优于治疗前，差异均有统计学意义（P<0.05），而治疗前后患者体质量并未发生明显变化，差异无统计学意义（P＞0.05）。3例患者出现腹胀、4例患者出现腹泻等不良反应，经对症治疗后逐渐好转。结论口服阿卡波糖能够明显控制患者的血糖水平，并能够长期维持，不良反应较少，值得在临床上广泛使用。
目的：探討口服葡萄糖苷酶抑製劑阿卡波糖治療2型糖尿病的臨床效果，為2型糖尿病患者的用藥治療提供依據。方法選取2011年7月至2013年7月在該院住院的2型糖尿病患者80例，首次給予口服阿卡波糖75~150 mg，以後根據血糖水平進行箇體化調整劑量，口服治療3箇月後，觀察患者空腹、餐後2小時血糖及糖化血紅蛋白的變化，以及治療前後的血脂、體質量變化，併觀察患者的不良反應。結果治療3箇月後，80例患者空腹、餐後2小時血糖以及糖化血紅蛋白明顯下降，治療後的血脂明顯優于治療前，差異均有統計學意義（P<0.05），而治療前後患者體質量併未髮生明顯變化，差異無統計學意義（P＞0.05）。3例患者齣現腹脹、4例患者齣現腹瀉等不良反應，經對癥治療後逐漸好轉。結論口服阿卡波糖能夠明顯控製患者的血糖水平，併能夠長期維持，不良反應較少，值得在臨床上廣汎使用。
목적：탐토구복포도당감매억제제아잡파당치료2형당뇨병적림상효과，위2형당뇨병환자적용약치료제공의거。방법선취2011년7월지2013년7월재해원주원적2형당뇨병환자80례，수차급여구복아잡파당75~150 mg，이후근거혈당수평진행개체화조정제량，구복치료3개월후，관찰환자공복、찬후2소시혈당급당화혈홍단백적변화，이급치료전후적혈지、체질량변화，병관찰환자적불량반응。결과치료3개월후，80례환자공복、찬후2소시혈당이급당화혈홍단백명현하강，치료후적혈지명현우우치료전，차이균유통계학의의（P<0.05），이치료전후환자체질량병미발생명현변화，차이무통계학의의（P＞0.05）。3례환자출현복창、4례환자출현복사등불량반응，경대증치료후축점호전。결론구복아잡파당능구명현공제환자적혈당수평，병능구장기유지，불량반응교소，치득재림상상엄범사용。
Objective To explore the clinical efficacy of acarbose-glycosidase inhibitor for type 2 diabetes mellitus (T2DM),in order to provide the basis for drug treatment of T2DM patients. Methods A total of 80 patients with T2DM,who hos-pitalized from June 2011 to June 2013 ,were administered with 75-150 mg acarbose orally for the first time ,then the dosage was adjusted individually according to the blood glucose level. 3 months after oral medication ,the changes of fast plasma glucose (FPG),2hPG,glycosylated hemoglobin,and the changes of serum lipid and body mass before and after treatment were observed, as well as the adverse reactions. Results Three months after treatment,the levels of FPG,2hPG and glycosylated hemoglobin of all the 80 cases decreased obviously ,and the serum lipid after treatment was better than that before treatment with statistically significant difference(P<0.05);the body mass had no obvious change before and after treatment,and the difference had no statis tical significance(P>0.05). Abdominal distention appeared in 3 cases,diarrhea and other adverse reactions occurred in 4 cases, which all were getting better gradually after symptomatic treatment. Conclusion Oral acarbose can obviously control the patient′s blood sugar level with long-term maintenance and less adverse reactions ,so it is worthy of application widely in clinic.
