CAJ | 학술논문

小分子核糖核酸(MicroRNA)作为肺癌早期的一种新的生物标志物，为肺癌的诊断提供了一种新的方法。MicroRNA 在肿瘤发生发展过程中发挥癌基因和抑癌基因的作用。MicroRNA 与肺癌增殖、侵袭、治疗、预后和复发有着密切关系。DNA 甲基化是目前最主要的一种表观遗传修饰形式，抑癌基因的高甲基化使 DNA 染色质构象发生改变导致转录失活，引起肿瘤发生。DNA 甲基化和 MicroRNA在功能上相互调控，对肺癌的发生、发展同样重要。
소분자핵당핵산(MicroRNA)작위폐암조기적일충신적생물표지물，위폐암적진단제공료일충신적방법。MicroRNA 재종류발생발전과정중발휘암기인화억암기인적작용。MicroRNA 여폐암증식、침습、치료、예후화복발유착밀절관계。DNA 갑기화시목전최주요적일충표관유전수식형식，억암기인적고갑기화사 DNA 염색질구상발생개변도치전록실활，인기종류발생。DNA 갑기화화 MicroRNA재공능상상호조공，대폐암적발생、발전동양중요。
As a new kind of early lung cancer biomarker,MicroRNA provides a new method for the diagnosis of lung cancer.MicroRNA plays the role of oncogene and tumor suppressor genes in the process of cancer development.MicroRNA is closely related to proliferation,invasion,treatment,prognosis,and recurrence of lung cancer.DNA methylation is one of the most major forms of epigenetic modifications, high methylation of tumor suppressor genes causes conformation changes of DNA chromatin leading to transcriptional inactivation,thus it arouses tumorigenesis.DNA methylation and MicroRNA regulate each other and play an equally importance in lung cancer development.