CAJ | 학술논문

目的：探讨一口气法与重复呼吸法对人群肺弥散功能的检测价值。方法选取2010年1月至2013年10月我院收治的34例间质性肺疾病(ILD)患者以及36例 COPD 患者,分别将其设为 ILD组以及 COPD 组,另外选取33名健康人设为对照组。分别采用一口气法与重复呼吸法对其肺弥散功能进行检测。结果 ILD 组和 COPD 组的肺功能指标分别与对照组相比,差异均有统计学意义(P <0.05)。对照组采用重复呼吸法测定 DL CO%pred 的平均值[(78.91±2.24)%]低于80%。校正前,3组用一口气法及重复呼吸法测得的 DL CO% pred、DL CO/AV% pred 相比,差异均有统计学意义(P <0.05)。COPD 组校正后采用2种测试方法测得的 DL CO% pred、DL CO/AV% pred 与 ILD 组相比,差异均有统计学意义(P <0.05)。一口气法的检测时间平均为(11.28±0.14)s,明显短于重复呼吸法的检测时间[(86.13±3.25)s,P <0.05]。重复呼吸法测得的 DL CO/AV%pred 与测试时间的相关性(r =-0.661,P <0.01),相比于 DL CO%pred 与测试时间的相关性(r =0.391,P <0.01)明显增高,差异有统计学意义(P <0.05)。校正前采取2种不同方法测得 ILD 组轻、重度及 COPD 组轻度的DL CO%pred 相比,差异均有统计学意义(P <0.05)。校正后 ILD 组轻、重度患者采取2种不同方法测得的 DL CO%pred 相比,差异均有统计学意义(P <0.05)。结论相比于一口气法,对老年患者、不能屏气者、存在 ILD 以及 COPD 患者而言,采用重复呼吸法检测肺弥散功能无需受试者屏气,测量结果可能具有更高的参考价值。
목적：탐토일구기법여중복호흡법대인군폐미산공능적검측개치。방법선취2010년1월지2013년10월아원수치적34례간질성폐질병(ILD)환자이급36례 COPD 환자,분별장기설위 ILD조이급 COPD 조,령외선취33명건강인설위대조조。분별채용일구기법여중복호흡법대기폐미산공능진행검측。결과 ILD 조화 COPD 조적폐공능지표분별여대조조상비,차이균유통계학의의(P <0.05)。대조조채용중복호흡법측정 DL CO%pred 적평균치[(78.91±2.24)%]저우80%。교정전,3조용일구기법급중복호흡법측득적 DL CO% pred、DL CO/AV% pred 상비,차이균유통계학의의(P <0.05)。COPD 조교정후채용2충측시방법측득적 DL CO% pred、DL CO/AV% pred 여 ILD 조상비,차이균유통계학의의(P <0.05)。일구기법적검측시간평균위(11.28±0.14)s,명현단우중복호흡법적검측시간[(86.13±3.25)s,P <0.05]。중복호흡법측득적 DL CO/AV%pred 여측시시간적상관성(r =-0.661,P <0.01),상비우 DL CO%pred 여측시시간적상관성(r =0.391,P <0.01)명현증고,차이유통계학의의(P <0.05)。교정전채취2충불동방법측득 ILD 조경、중도급 COPD 조경도적DL CO%pred 상비,차이균유통계학의의(P <0.05)。교정후 ILD 조경、중도환자채취2충불동방법측득적 DL CO%pred 상비,차이균유통계학의의(P <0.05)。결론상비우일구기법,대노년환자、불능병기자、존재 ILD 이급 COPD 환자이언,채용중복호흡법검측폐미산공능무수수시자병기,측량결과가능구유경고적삼고개치。
Objective To investigate value of different methods for the detection of pulmonary diffusing capacity of the population.Methods 34 cases of interstitial lung disease (ILD)and 36 cases of chronic obstructive pulmonary disease (COPD)from January 2010 to October 2013 in our hospital were seceted respectively,and were set to ILD group and COPD group,while 33 cases of healthy people were seceted as control group.Breathing method and repeat breathing method were used to detect pulmonary diffusion function of patients.Results The lung function in ILD group and COPD group was statistically different from control group (P <0.05).DL CO%pred in control group by repeat breathing method was (78.91 ± 2.24 )%,less than 80%.Before correction,DL CO% pred,DL CO/AV% pred by two different methods were statistically different in three groups (P < 0.05 ).After correction,DL CO% pred, DL CO/AV%pred by two different methods between COPD group and ILD group (P < 0.05 ).The average time by breathing method was (1 1.28 ± 0.14 ) s,significantly shorter than that by repeat breathing method [(86.13 ± 3.25 )s,P < 0.05 ].The correlation between DL CO/AV% pred by repeat breathing method and test time (r = -0.661,P < 0.01 )was significantly increased compared to the correlation between DL CO%pred and test time (r =0.391,P <0.01).Before correction,DL CO%pred by two different methods was statistically different in mild and severe ILD group,mild COPD group (P <0.05).After correcting,DL CO% pred by two different methods was statistically different in mild and severe ILD group (P < 0.05 ).Conclusions Compared to breath method,elderly patients who can not breath,and together with interstitial lung diseaseand chronic obstructive pulmonary disease,detection of pulmonary diffusion by repeat breathing method is without subjects,the measurement results may have more high reference value.