CAJ | 학술논문

目的：检测非小细胞肺癌(NSCLC)患者中 EML4-ALK 基因的表达率并分析其与患者的临床病理学特征的关系。方法用荧光 PCR 法检测我院98例 NSCLC 患者肿瘤组织中 EML4-ALK 基因的表达。结果98例 NSCLC 患者中检测出6例有 EML4-ALK 基因的表达,表达率为6.12%。6例阳性患者中,4例为女性,2例为男性；不吸烟者4例,吸烟者2例；年龄<50岁者5例,≥50岁者1例；5例为腺癌患者,1例为腺鳞癌患者；5例为中分化患者,1例为低分化患者,高分化患者中未发现阳性。结论 EML4-ALK 融合基因代表了 NSCLC 的一个新的分子亚型,表达 EML4-ALK 融合基因的NSCLC 具有其独特的临床病理学特点。
목적：검측비소세포폐암(NSCLC)환자중 EML4-ALK 기인적표체솔병분석기여환자적림상병이학특정적관계。방법용형광 PCR 법검측아원98례 NSCLC 환자종류조직중 EML4-ALK 기인적표체。결과98례 NSCLC 환자중검측출6례유 EML4-ALK 기인적표체,표체솔위6.12%。6례양성환자중,4례위녀성,2례위남성；불흡연자4례,흡연자2례；년령<50세자5례,≥50세자1례；5례위선암환자,1례위선린암환자；5례위중분화환자,1례위저분화환자,고분화환자중미발현양성。결론 EML4-ALK 융합기인대표료 NSCLC 적일개신적분자아형,표체 EML4-ALK 융합기인적NSCLC 구유기독특적림상병이학특점。
Objective To detect the frequency of EML4-ALK fusion gene in non-small cell lung cancer (NSCLC)patients,and to analyze the relationship between EML4-ALK fusion gene and clinical features.Methods The EML4-ALK fusion gene was identified by fluorensce PCR in 98 patients with NSCLC.Results In 98 patients,six specimens (6.12%)were identified with EML4-ALK fusion genes. Among six EML4-ALK-positive samples,four cases were female,two cases were male,four cases were non-smokers,two cases were smokers,five cases were younger than 50 years old,one case was elder than 50 years old,and five cases were adonocarcinoma,one case was adenosquamous carcinoma.Conclusions EML4-ALK fusion gene defines a new molecular subset of NSCLC.NSCLC with EML4-ALK fusion gene has distinct characteristics.