CAJ | 학술논문

目的：比较老年抑郁症（GD）和阿尔茨海默病（AD）的事件相关电位N400的差异性，寻找辅助诊断GD的新方法。方法选择35例GD患者，40例AD患者和39例健康老人（NC）分别进行N400检测。结果（1）三组N400潜伏期比较，Fz区、Pz区、C3区、C4区非匹配刺激潜伏期之间的差异，Pz区匹配刺激潜伏期之间的差异有统计学意义（P＜0.05）。GD组N400潜伏期长于NC组，AD组N400潜伏期长于GD组。（2）三组N400波幅比较，Pz、C4区三组非匹配和匹配刺激波幅之间的差异，Fz、C3区匹配刺激波幅之间的差异有统计学意义（P＜0.05）。GD组N400波幅低于NC组，AD组N400波幅低于GD组。结论（1）GD和AD患者存在N400的异常及认知功能的损害，GD的异常程度介于AD和NC之间。（2）N400对GD和AD的诊断具有辅助价值。
목적：비교노년억욱증（GD）화아이자해묵병（AD）적사건상관전위N400적차이성，심조보조진단GD적신방법。방법선택35례GD환자，40례AD환자화39례건강노인（NC）분별진행N400검측。결과（1）삼조N400잠복기비교，Fz구、Pz구、C3구、C4구비필배자격잠복기지간적차이，Pz구필배자격잠복기지간적차이유통계학의의（P＜0.05）。GD조N400잠복기장우NC조，AD조N400잠복기장우GD조。（2）삼조N400파폭비교，Pz、C4구삼조비필배화필배자격파폭지간적차이，Fz、C3구필배자격파폭지간적차이유통계학의의（P＜0.05）。GD조N400파폭저우NC조，AD조N400파폭저우GD조。결론（1）GD화AD환자존재N400적이상급인지공능적손해，GD적이상정도개우AD화NC지간。（2）N400대GD화AD적진단구유보조개치。
ObjectiveTo compare the characteristics of N400 in patients with geriatric depression (GD) and Alzheimer disease(AD), and look for a new way of diagnosis of GD.Methods35 patients with geriatric depression(GD group), 40 Alzheimer disease(AD group) and 39 healthy elderly controls(NC group) were collected and N400 were detected.ResultsThe N400 latencies of Fz, Pz, C3, C4 in mismatching sentence and Pz in matching sentence showed statistically significant differences among three groups(P<0.05). N400 latencies in GD group were longer than those in control group, N400 latencies were longer in AD group than those in GD group. The N400 amplitudes of Pz and C4 in mismatching sentence and matching sentence showed statistically significant differences among three groups(P<0.05). The N400 amplitudes of Fz and C3 in matching sentence had both statistically significant differences in three groups(P<0.05). N400 amplitudes in GD group were lower than those in control group, N400 amplitudes were lower in AD group than those in GD group.ConclusionThe patients with AD and GD have impairment in their cognitive function and N400. Event related potential N400 is valuable in the diagnosis of GD and AD.