CAJ | 학술논문

目的：了解胃癌组织中环氧酶-2（COX-2）和白细胞介素-17（IL-17）的表达，COX-2的表达与胃癌临床病理特征间的关系及两者的相关性。方法收集60例胃癌患者和20例健康对照者的组织标本。胃癌患者包括男44例，女16例，平均年龄（61.8±10.9）岁。根据TNM分期将胃癌分为TNMⅠ期（7例）、Ⅱ期（8例）、Ⅲ期（32例）和Ⅳ期（13例）；按组织分化程度分为低分化组（34例）和中-高分化组（26例）；按发病部位分为贲门癌（7例）和非贲门癌（53例）；按有无淋巴结转移分为有转移（43例）和无转移（17例）。采用免疫组织化学染色测定胃癌组织中COX-2和IL-17的表达。结果胃癌组织中COX-2和IL-17的表达明显高于对照组，胃癌组织中COX-2的表达水平与胃癌的临床分期、有无淋巴结转移、肿瘤大小及分化程度有关（P＜0.01），与患者的年龄、性别、肿瘤部位无关（P＞0.05）。胃癌组织中COX-2的表达水平与IL-17的表达水平呈正相关（P＜0.001）。结论 COX-2和IL-17在胃癌的发生和发展中起促进作用，COX-2和IL-17可能互为正向调节因素。
목적：료해위암조직중배양매-2（COX-2）화백세포개소-17（IL-17）적표체，COX-2적표체여위암림상병리특정간적관계급량자적상관성。방법수집60례위암환자화20례건강대조자적조직표본。위암환자포괄남44례，녀16례，평균년령（61.8±10.9）세。근거TNM분기장위암분위TNMⅠ기（7례）、Ⅱ기（8례）、Ⅲ기（32례）화Ⅳ기（13례）；안조직분화정도분위저분화조（34례）화중-고분화조（26례）；안발병부위분위분문암（7례）화비분문암（53례）；안유무림파결전이분위유전이（43례）화무전이（17례）。채용면역조직화학염색측정위암조직중COX-2화IL-17적표체。결과위암조직중COX-2화IL-17적표체명현고우대조조，위암조직중COX-2적표체수평여위암적림상분기、유무림파결전이、종류대소급분화정도유관（P＜0.01），여환자적년령、성별、종류부위무관（P＞0.05）。위암조직중COX-2적표체수평여IL-17적표체수평정정상관（P＜0.001）。결론 COX-2화IL-17재위암적발생화발전중기촉진작용，COX-2화IL-17가능호위정향조절인소。
ObjectiveTo explore the expression level of COX-2 and IL-17 in gastric cancer tissues, correlation between expression of COX-2 and clinical pathological characteristics of gastric cancer, and relationship between expression of COX-2 and IL-17.MethodsThe expression of COX-2 and IL-17 was determined by immunohistochemistry from 60 patients with gastric cancer and 20 healthy controls. Gastric cancer patients included 44 males and 16 females with average age (61.8±10.9) years old. Gastric cancer were divided into TNM stageⅠ(7 cases),Ⅱ(8 cases),Ⅲ(32 cases) andⅣ(13 cases) according to the TNM staging; low differentiation group (34 cases) and moderate- well differentiation group (26 cases) according to the degree of differentiation; cardiac carcinoma (7 cases) and non cardiac carcinoma (53 cases) according to the location of cancer; with the lymph node metastasis (43 cases) and without metastasis (17 cases) according to the lymph node metastasis.ResultsCompared with healthy controls, increased expression of COX-2 and IL-17 was showed in gastric cancer tissues. Intratumoral expression of COX-2 was significantly correlated with tumor stage, lymphnode metastasis, tumor size and degree of differentiation, but had no relation with age, gender and location. The expression of COX-2 had positive correlation with that of IL-17 in cancer tissues.ConclusionCOX-2 and IL-17 might play a promotion effect in the development and progression of gastric cancer. COX-2 and IL-17 might be mutually positive regulatory factors.