CAJ | 학술논문

目的：评价芬太尼透皮贴和吗啡缓释片在控制中重度癌痛的效果及不良反应的情况。方法以“芬太尼透皮贴∕多瑞吉∕吗啡∕美菲康∕癌症∕癌痛∕随机∕对照”为关键词，检索公开发表的相关随机对照试验。根据澳大利亚JBI循证卫生保健中心对RCT的评价原则进行文献评价，采用RevMan 5．0软件对本系统评价关注的结局指标进行M eta分析。结果共纳入10篇文献，疼痛缓解率差异无统计学意义，头晕嗜睡、恶心呕吐、便秘发生率差异有统计学意义。结论芬太尼透皮贴剂和口服吗啡控释片治疗中重度癌痛的效果相近，但芬太尼透皮贴剂头晕嗜睡、恶心呕吐、便秘等主要不良反应的发生率较低。
목적：평개분태니투피첩화마배완석편재공제중중도암통적효과급불량반응적정황。방법이“분태니투피첩∕다서길∕마배∕미비강∕암증∕암통∕수궤∕대조”위관건사，검색공개발표적상관수궤대조시험。근거오대리아JBI순증위생보건중심대RCT적평개원칙진행문헌평개，채용RevMan 5．0연건대본계통평개관주적결국지표진행M eta분석。결과공납입10편문헌，동통완해솔차이무통계학의의，두훈기수、악심구토、편비발생솔차이유통계학의의。결론분태니투피첩제화구복마배공석편치료중중도암통적효과상근，단분태니투피첩제두훈기수、악심구토、편비등주요불량반응적발생솔교저。
Objective To evaluate the effect of fentanyl transdermal patches and release morphine tablets for the control of moderate to severe cancer pain and adverse reactions by meta-analysis .Method“Fentanyl transdermal pat-ches /Durogesic /morphine /Meifeikang/cancer/cancer pain/random /control” was selected as key words ,the relevant published randomized controlled trials was retrieved based on databases .Literature was evaluated by RCT evaluation principles based on JBI evidence-based health care centers in Australia ,RevMan5 .0 software was used for meta-analysis to evaluate the system concern outcomes index .Result The meta-analysis included 10 trials .Remission rate of pain in both fentanyl transdermal patches and controlled-release oral morphine tablets was no significant difference .There were significant difference in incidence of dizziness ,drowsiness ,nausea ,vomiting and constipa-tion .Conclusion Both fentanyl transdermal and controlled-release oral morphine tablets had the same effect in the treatment of patients with moderate to severe cancer pain ,but the former might have lower incidence of adverse reac-tion .