CAJ | 학술논문

目的：测定多黏菌素 B 和米诺环素对泛耐药鲍曼不动杆菌的体外抗菌活性，为临床治疗药物选择提供实验室依据。方法对39株临床分离的泛耐药鲍曼不动杆菌，采用 K-B 法测定多黏菌素 B、米诺环素的药物敏感情况。结果38株泛耐药鲍曼不动杆菌对多黏菌素 B 敏感，敏感率为97．4％；20株对米诺环素敏感，敏感率为51．3％；多黏菌素 B 的敏感性明显高于米诺环素（P ＜0．05）。结论多黏菌素 B 对泛耐药鲍曼不动杆菌的体外抗菌活性较高，可作为治疗这类感染的首选。
목적：측정다점균소 B 화미낙배소대범내약포만불동간균적체외항균활성，위림상치료약물선택제공실험실의거。방법대39주림상분리적범내약포만불동간균，채용 K-B 법측정다점균소 B、미낙배소적약물민감정황。결과38주범내약포만불동간균대다점균소 B 민감，민감솔위97．4％；20주대미낙배소민감，민감솔위51．3％；다점균소 B 적민감성명현고우미낙배소（P ＜0．05）。결론다점균소 B 대범내약포만불동간균적체외항균활성교고，가작위치료저류감염적수선。
Objective To investigate the in vitro susceptibility of Minocycline and polymycin B against clinical islates of pan-drug resistant Acinetobacter baumanii ,to provide laboratory support for clinical treatment for drug selection.Methods The susceptible test of Minocycline and polymycin against 39 isolates of pan-drug resistant Acinetobacter baumanii were determined by K-B meth-od.Results 38 strains of pan-resistant Acinetobacter baumanii were sensitive to polymyxin B,sensitive rate was 97.4%,20 strains sensitive to minocycline,the sensitivity rate was 51.3%.polymyxin B sensitivity was more sensitive than Minocycline (P < 0.05). Conclusion Polymycin B had strong activit ies against pan-drug resistant Acinetobacter baumanii .