CAJ | 학술논문

目的：探讨维生素 D 对慢性阻塞性肺疾病（COPD）患者肺功能的影响，并探索其可能的机制。方法将入院治疗的COPD 患者，随机分成2组，第1组患者给予常规的 COPD 治疗（对照组，30例），第2组患者（治疗组，30例）在常规治疗的基础上给予维生素 D 口服。检测2组患者的肺功能指标：患者一秒用力呼气容积（FEV1）占预计值百分比，以及一秒用力呼气量与用力肺活量比值（FEV1/FVC）。测定患者血清 C 反应蛋白（CRP）水平，并通过血气分析比较2组患者治疗前后动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）的变化。结果与对照组比较，实验组患者的肺功能的改善更为明显，急性发作次数减少（P ＜0．05）；同时，实验组 CRP 水平治疗后与治疗前比较明显降低（P ＜0．05），而对照组治疗前后比较差异无统计学意义（P ＞0．05）。结论维生素 D 的加用有助于 COPD 患者肺功能的改善，其机制可能与改善患者的炎症反应状态有关。
목적：탐토유생소 D 대만성조새성폐질병（COPD）환자폐공능적영향，병탐색기가능적궤제。방법장입원치료적COPD 환자，수궤분성2조，제1조환자급여상규적 COPD 치료（대조조，30례），제2조환자（치료조，30례）재상규치료적기출상급여유생소 D 구복。검측2조환자적폐공능지표：환자일초용력호기용적（FEV1）점예계치백분비，이급일초용력호기량여용력폐활량비치（FEV1/FVC）。측정환자혈청 C 반응단백（CRP）수평，병통과혈기분석비교2조환자치료전후동맥혈양분압（PaO2）、동맥혈이양화탄분압（PaCO2）적변화。결과여대조조비교，실험조환자적폐공능적개선경위명현，급성발작차수감소（P ＜0．05）；동시，실험조 CRP 수평치료후여치료전비교명현강저（P ＜0．05），이대조조치료전후비교차이무통계학의의（P ＞0．05）。결론유생소 D 적가용유조우 COPD 환자폐공능적개선，기궤제가능여개선환자적염증반응상태유관。
Objective To investigate the effect of vitamin D on pulmonary function in patients with chronic obstructive pulmona-ry disease,and to explore its possible mechanism.Methods Patients with chronic obstructive pulmonary disease admitted in the hospital were randomly divided into 2 groups,one group of patients were given regular COPD treatment (control group,30 cases), the other group of patients were given vitamin D on the basis of conventional therapy(experimental group,30 cases).Pulmonary function test and C reaction protein (CRP)determination in the 2 groups were performed,the contents of PaO2 ,PaCO2 were also determined.Results Compared with the control group,lung function improvement in experimental group were more obvious,and the the number of acute attack significantly reduced(P <0.05).The concentration of CRP in experimental group was significantly lower after treatment than before treatment(P <0.05),while the concentration of CRP in control group didn′t change significantly (P >0.05).Conclusion Vitamin D contributes to the improvement of pulmonary function in patients with COPD,and its mecha-nism might relate to the reduction of inflammatory reaction.