国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
17期
2311-2312
,共2页
DNA,乙型肝炎病毒%肝纤维化%慢性乙型肝炎
DNA,乙型肝炎病毒%肝纖維化%慢性乙型肝炎
DNA,을형간염병독%간섬유화%만성을형간염
DNA,hepatitis B virus%hepatic fibrosis%chronic hepatitis B
目的：探讨慢性乙型肝炎患者血清 HBV-DNA 水平与肝纤维化血清指标之间的关联。方法用实时荧光定量 PCR法检测 HBV-DNA 水平、用化学发光法检测肝纤维化指标：透明质酸、Ⅲ型前胶原、Ⅳ型胶原、层粘连蛋白。结果110例乙型肝炎患者血清 HBV-DNA 水平（对数值）为5．32±1．37，透明质酸水平为（197．81±85．37）mg/mL，Ⅲ型前胶原水平为（142．66±30．28）μg/mL，Ⅳ型胶原水平为（90．34±20．53）μg/mL，层粘连蛋白水平为（143．96±31．79）μg/mL，均高于对照组（P ＜0．01）。患者血清 HBV-DNA 水平与肝纤维化4项血清指标之间的相关性较弱，无统计学意义（P ＞0．05）。结论慢性乙型肝炎患者肝纤维化4项血清指标上升，但患者血清 HBV-DNA 水平与肝纤维化血清指标检测值之间没有显著的相关性。
目的：探討慢性乙型肝炎患者血清 HBV-DNA 水平與肝纖維化血清指標之間的關聯。方法用實時熒光定量 PCR法檢測 HBV-DNA 水平、用化學髮光法檢測肝纖維化指標：透明質痠、Ⅲ型前膠原、Ⅳ型膠原、層粘連蛋白。結果110例乙型肝炎患者血清 HBV-DNA 水平（對數值）為5．32±1．37，透明質痠水平為（197．81±85．37）mg/mL，Ⅲ型前膠原水平為（142．66±30．28）μg/mL，Ⅳ型膠原水平為（90．34±20．53）μg/mL，層粘連蛋白水平為（143．96±31．79）μg/mL，均高于對照組（P ＜0．01）。患者血清 HBV-DNA 水平與肝纖維化4項血清指標之間的相關性較弱，無統計學意義（P ＞0．05）。結論慢性乙型肝炎患者肝纖維化4項血清指標上升，但患者血清 HBV-DNA 水平與肝纖維化血清指標檢測值之間沒有顯著的相關性。
목적：탐토만성을형간염환자혈청 HBV-DNA 수평여간섬유화혈청지표지간적관련。방법용실시형광정량 PCR법검측 HBV-DNA 수평、용화학발광법검측간섬유화지표：투명질산、Ⅲ형전효원、Ⅳ형효원、층점련단백。결과110례을형간염환자혈청 HBV-DNA 수평（대수치）위5．32±1．37，투명질산수평위（197．81±85．37）mg/mL，Ⅲ형전효원수평위（142．66±30．28）μg/mL，Ⅳ형효원수평위（90．34±20．53）μg/mL，층점련단백수평위（143．96±31．79）μg/mL，균고우대조조（P ＜0．01）。환자혈청 HBV-DNA 수평여간섬유화4항혈청지표지간적상관성교약，무통계학의의（P ＞0．05）。결론만성을형간염환자간섬유화4항혈청지표상승，단환자혈청 HBV-DNA 수평여간섬유화혈청지표검측치지간몰유현저적상관성。
Objective To explore the correlation between serum HBV-DNA content and hepatic fibrosis indicators in hchronic epatitis B patients.Methods Serum HBV-DNA content was determined by using real-time fluorescence quantitative PCR and he-patic fibrosis indicators including hyaluronic acid,laminin,procollagen Ⅲ,and collagen Ⅳ which were determined by using chemilu-minescence.Results The logarithm value of serum HBV-DNA content of the 110 hepatitis B patients was 5.32±1.37.Serum hyal-uronic acid concentration was (197.81 ±85.37)mg/mL;procollagen Ⅲ concentration was (142.66 ±30.28)μg/mL.Collagen Ⅳconcentration was (90.34 ±20.53)μg/mL.Laminin was (143.96 ±31.79 )μg/mL.All these indicators were significantly higher than the control group (P <0.01).But there were no significant linear correlation between serum HBV-DNA content and the four hepatic fibrosis indicators(P >0.05).Conclusion The hepatic fibrosis indicators increased significantly in hepatitis B patients but there were no significant correlations between serum HBV-DNA content and the hepatic fibrosis indicators.
