CAJ | 학술논문

目的：了解该院住院新生儿无乳链球菌败血症的临床特点及无乳链球菌的耐药性，为临床用药提供参考。方法采用 VITEK-2全自动微生物分析鉴定系统和临床实验室标准化协会（CLSI）2012年的判断标准，对该院临床分离的42株无乳链球菌的来源科室分布和药敏试验情况进行统计分析。结果早产新生儿监护病房3例、足月新生儿监护病房26例、儿童重症监护病房7例、极早产新生儿监护病房6例；无乳链球菌对氨苄西林、红霉素、克林霉素、喹努普汀/达福普汀、利奈唑烷、青霉素、四环素、替加环素、万古霉素、左氧氟沙星的耐药率分别为0．0％、69．0％、71．4％、0．0％、0．0％、0．0％、74．4％、0．0％、0．0％和38．1％。结论该院新生儿血流感染无乳链球菌对多种抗菌药物的耐药率较高，建议临床首选氨苄西林、青霉素，合理选用抗菌药物进行治疗。
목적：료해해원주원신생인무유련구균패혈증적림상특점급무유련구균적내약성，위림상용약제공삼고。방법채용 VITEK-2전자동미생물분석감정계통화림상실험실표준화협회（CLSI）2012년적판단표준，대해원림상분리적42주무유련구균적래원과실분포화약민시험정황진행통계분석。결과조산신생인감호병방3례、족월신생인감호병방26례、인동중증감호병방7례、겁조산신생인감호병방6례；무유련구균대안변서림、홍매소、극림매소、규노보정/체복보정、리내서완、청매소、사배소、체가배소、만고매소、좌양불사성적내약솔분별위0．0％、69．0％、71．4％、0．0％、0．0％、0．0％、74．4％、0．0％、0．0％화38．1％。결론해원신생인혈류감염무유련구균대다충항균약물적내약솔교고，건의림상수선안변서림、청매소，합리선용항균약물진행치료。
Objective To investigate clinical features and drug resistance of neonate septicemia caused by Streptococcus agalac-tiae in the hospital and to provide clinical guidance for treatment.Methods 42 Streptococcus agalactiae isolates in the hospital were identified and their department distribution as well as drug susceptibility was determined by using automatic VITEK-2 system and criteria released by CLSI in 2012.Results The number of cases in preterm neonatal intensive care unit,full-term neonatal intensive care unit,pediatric intensive care unit and extremely preterm neonatal intensive care unit were 3,26,7 and 6,respectively.The drug resistance rates of the isolated Streptococcus agalactiae to ampicillin,erythromycin,clindamycin,quinupristin/dalfopristin,linezolid, penicillin,tetracycline,tigecycline,vancomycin and levofloxacin were 0.0%,69.0%,71.4%,0.0%,0.0%,0.0%,74.4%,0.0%, 0.0% and 38.1%,respectively.Conclusion The antimicrobial resistance rates of Streptococcus agalactiae which caused neonatal septicemia in our hospital are relatively high.Ampicillin and penicillin are recomended in treatment for neonate septicemia caused by Streptococcus agalactiae .