CAJ | 학술논문

目的：探讨青海高原汉族人群 HLA-DRB71等位基因与原发性胆汁性肝硬化（PBC）发生的相关性。方法选取2011年3月至2013年3月于该院就诊的 PBC 患者95例（PBC 组），健康体检且结果合格者203例（对照组）。以序列特异性引物PCR 分析方法对两组的 HLA-DRB71等位基因进行分析研究。结果 PBC 组和对照组 HLA-DRB71*07基因频率分别为36．84％和13．79％，差异有统计学意义（P ＜0．05）；PBC 组其他 HLA-DRB71等位基因的频率低于对照组（P ＜0．05）；PBC 组HLA-DRB71*07阳性率与对照组比较，OR 值为2．67，差异有统计学意义（P ＜0．05）；所有携带有 HLA-DRB71*07等位基因的PBC 患者均有 HLA-DRB71*0701表达，但 HLA-DRB71*0703、HLA-DRB71*0704、HLA-DRB71*0705、HLA-DRB71*0706无表达。结论 HLA-DRB71*0701基因的表达与 PBC 的易患性有关，但不是独立危险因素。
목적：탐토청해고원한족인군 HLA-DRB71등위기인여원발성담즙성간경화（PBC）발생적상관성。방법선취2011년3월지2013년3월우해원취진적 PBC 환자95례（PBC 조），건강체검차결과합격자203례（대조조）。이서렬특이성인물PCR 분석방법대량조적 HLA-DRB71등위기인진행분석연구。결과 PBC 조화대조조 HLA-DRB71*07기인빈솔분별위36．84％화13．79％，차이유통계학의의（P ＜0．05）；PBC 조기타 HLA-DRB71등위기인적빈솔저우대조조（P ＜0．05）；PBC 조HLA-DRB71*07양성솔여대조조비교，OR 치위2．67，차이유통계학의의（P ＜0．05）；소유휴대유 HLA-DRB71*07등위기인적PBC 환자균유 HLA-DRB71*0701표체，단 HLA-DRB71*0703、HLA-DRB71*0704、HLA-DRB71*0705、HLA-DRB71*0706무표체。결론 HLA-DRB71*0701기인적표체여 PBC 적역환성유관，단불시독립위험인소。
Objective To investigate the correlation between HLA-DRB71 allele and primary biliary cirrhosis(PBC)of Han pop-ulation in Qinghai plateau.Methods 95 PBC patients from March 2011 to March 2013 in the hospital were enrolled in the study (PBC group),203 cases of healthy individuals were recruited as control group.By using a sequence specific primer PCR method,the HLA-DRB71 alleles in the two groups were analyzed.Results HLA-DRB71*07 gene frequencies in PBC group and control group were 36.84% and 13.79% respectively,the difference was statistically significant(P <0.05).In PBC group,the other HLA-DRB71 alleles′frequency were lower than that in control group(P <0.05).There was a higher positive rate of HLA-DRB71 * 07 in PBC group than control group,and the OR value is 2.67(P <0.05).All the PCB patients carring HLA-DRB71 *07 alleles were HLA-DRB71*0701,but other subtypes such as HLA-DRB71 *0703,HLA-DRB71 *0704,HLA-DRB71 *0705,HLA-DRB71 *0706 were not found.Conclusion PBC Susceptibility might associated with HLA-DRB71 *0701 alleles,but is not an independent risk factor.