CAJ | 학술논문

目的：对雄激素受体（AR）基因中 GGN 三核苷酸重复序列多态性与前列腺癌风险的相关性研究进行总结并得出一致性的结论。方法检索中国知网（CNKI）、维普（VIP）、万方、PubMed/Medline、Embase 和 The Cochrance Library 等电子数据库中关于 AR 基因 GGN 三核苷酸重复序列多态性与前列腺癌风险相关性研究的文献。以16个 GGN 序列为临界值，对 GGN 多态性重复长度与前列腺癌风险的相关性进行 meta 分析。结果共纳入9篇病例对照研究文献，共组成2438个病例和1968个对照。GGN 重复序列小于或等于16个者有更高的患前列腺癌的风险（OR ＝1．15，95％CI ：1．00～1．31，P ＝0．04）。结论 AR 基因中的重复 GGN 序列小于或等于16个与前列腺癌风险的增加有关。
목적：대웅격소수체（AR）기인중 GGN 삼핵감산중복서렬다태성여전렬선암풍험적상관성연구진행총결병득출일치성적결론。방법검색중국지망（CNKI）、유보（VIP）、만방、PubMed/Medline、Embase 화 The Cochrance Library 등전자수거고중관우 AR 기인 GGN 삼핵감산중복서렬다태성여전렬선암풍험상관성연구적문헌。이16개 GGN 서렬위림계치，대 GGN 다태성중복장도여전렬선암풍험적상관성진행 meta 분석。결과공납입9편병례대조연구문헌，공조성2438개병례화1968개대조。GGN 중복서렬소우혹등우16개자유경고적환전렬선암적풍험（OR ＝1．15，95％CI ：1．00～1．31，P ＝0．04）。결론 AR 기인중적중복 GGN 서렬소우혹등우16개여전렬선암풍험적증가유관。
Objective To provide a powerful and conclusive result for the association between the GGN polymorphic repeats in androgen receptor (AR)gene and prostate cancer (PCa)risk.Methods CNKI,VIP,Wanfang,PubMed/Medline,Embase and The Cochrance Library electronic database were used to retrieve the eligible publications addressing the association between the AR gene GGN polymorphic repeats and prostate cancer risk.16 GGN polymorphism repeats were used as cut off value,meta-analysis was ap-plied to the study on the association between the length of polymorphism repeats and prostate cancer risk.Results 9 cases of con-trol studies were included in this meta-analysis and a total of 2 438 cases and 1 968 controls were included.People with ≤16 GGN polymorphism repeats displayed a higher risk of prostate cancer(OR =1.15,95%CI :1.00 -1.31,P =0.04).Conclusion ≤16 GGN polymorphism repeats polymorphism associated with increased risk of prostate cancer.