国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
17期
2291-2292
,共2页
维生素 D%原发性高血压%收缩压%舒张压%变异系数
維生素 D%原髮性高血壓%收縮壓%舒張壓%變異繫數
유생소 D%원발성고혈압%수축압%서장압%변이계수
vitamin D%essential hypertension%systolic pressure%diastolic pressure%coefficient of variation
目的：探讨按一定剂量规范补充维生素 D 对原发性高血压患者血压控制效果的影响。方法选取高血压患者100例，按自愿原则随机分为2组，每组50例。其中一组作为对照组，仅按照标准进行规范治疗；另一组作为实验组，在规范治疗的同时每日辅以25μg 的维生素 D 治疗。运用酶联免疫吸附测定（ELISA）检测各组血清25-羟基维生素 D[25（OH）D]水平。跟踪时间持续1年，其间监测各组血压控制情况，计算两组收缩压及舒张压的均值及变异系数，对两组结果进行比较。结果实验组血清25（OH）D 水平为（110．3±24．5）μg/L，收缩压为（144±16）mm Hg，收缩压的变异系数（CV1）为11．1％，舒张压（87±9）mm Hg，舒张压的变异系数（CV2）为10．3％；对照组血清25（OH）D 水平为（30．1±14．9）μg/L，收缩压为（145±27）mm Hg，CV1为18．6％，舒张压（89±10）mm Hg，CV2为12．4％。实验组与对照组比较，25（OH）D 水平、CV1的差异有统计学意义（P ＜0．01），舒张压及 CV2的差异无统计学意义（P ＞0．05）。结论规范治疗原发性高血压的同时定剂量补充维生素 D，有利于原发性高血压患者收缩压的控制，但对舒张压无明显影响。
目的：探討按一定劑量規範補充維生素 D 對原髮性高血壓患者血壓控製效果的影響。方法選取高血壓患者100例，按自願原則隨機分為2組，每組50例。其中一組作為對照組，僅按照標準進行規範治療；另一組作為實驗組，在規範治療的同時每日輔以25μg 的維生素 D 治療。運用酶聯免疫吸附測定（ELISA）檢測各組血清25-羥基維生素 D[25（OH）D]水平。跟蹤時間持續1年，其間鑑測各組血壓控製情況，計算兩組收縮壓及舒張壓的均值及變異繫數，對兩組結果進行比較。結果實驗組血清25（OH）D 水平為（110．3±24．5）μg/L，收縮壓為（144±16）mm Hg，收縮壓的變異繫數（CV1）為11．1％，舒張壓（87±9）mm Hg，舒張壓的變異繫數（CV2）為10．3％；對照組血清25（OH）D 水平為（30．1±14．9）μg/L，收縮壓為（145±27）mm Hg，CV1為18．6％，舒張壓（89±10）mm Hg，CV2為12．4％。實驗組與對照組比較，25（OH）D 水平、CV1的差異有統計學意義（P ＜0．01），舒張壓及 CV2的差異無統計學意義（P ＞0．05）。結論規範治療原髮性高血壓的同時定劑量補充維生素 D，有利于原髮性高血壓患者收縮壓的控製，但對舒張壓無明顯影響。
목적：탐토안일정제량규범보충유생소 D 대원발성고혈압환자혈압공제효과적영향。방법선취고혈압환자100례，안자원원칙수궤분위2조，매조50례。기중일조작위대조조，부안조표준진행규범치료；령일조작위실험조，재규범치료적동시매일보이25μg 적유생소 D 치료。운용매련면역흡부측정（ELISA）검측각조혈청25-간기유생소 D[25（OH）D]수평。근종시간지속1년，기간감측각조혈압공제정황，계산량조수축압급서장압적균치급변이계수，대량조결과진행비교。결과실험조혈청25（OH）D 수평위（110．3±24．5）μg/L，수축압위（144±16）mm Hg，수축압적변이계수（CV1）위11．1％，서장압（87±9）mm Hg，서장압적변이계수（CV2）위10．3％；대조조혈청25（OH）D 수평위（30．1±14．9）μg/L，수축압위（145±27）mm Hg，CV1위18．6％，서장압（89±10）mm Hg，CV2위12．4％。실험조여대조조비교，25（OH）D 수평、CV1적차이유통계학의의（P ＜0．01），서장압급 CV2적차이무통계학의의（P ＞0．05）。결론규범치료원발성고혈압적동시정제량보충유생소 D，유리우원발성고혈압환자수축압적공제，단대서장압무명현영향。
Objective To investigate the standard supplement of a certain dose of vitamin D for blood pressure control in pa-tients with essential hypertension.Methods 100 cases of patients with essential hypertension were randomly divided into 2 groups voluntarily,50 cases in each group.One group were set as control group,in which patients underwent a standard treatment.The other group was experimental group,in which 25 μg/d vitamin D was administrated in addition to standard treatment.Serum 25-hydroxyvitamin D[25 (OH)D]concentrations were measured by enzyme-linked immunosorbent assay(ELISA)and patients were followed up for one year to observe the situation of blood pressure controll.Mean and variable coefficient(CV)of systolic and dias-tolic blood pressure were calculated and compared between groups.Results In experiment group,the serum 25 (OH)D concentra-tion was (110.3±24.5)μg/L,systolic pressure was (144±16)mm Hg,variable coefficient of systolic pressure(CV1)was 11.1%, diastolic pressure was (87±9)mm Hg,variable coefficient of diastolic pressure(CV2)was 10.3%.While in control group,the 25 (OH)D concentration was (30.1±14.9)μg/L,systolic pressure was (145 ±26)mm Hg,CV1 was 17.9%,diastolic pressure was (87±10)mm Hg,CV2 was 12.4%.Serum 25(OH)D concentration and CV1 were statistically different between the two groups(P<0.01),CV2 was not statistically different(P >0.05).Conclusion Administrate quantitative vitamin D in addition to standard treat-ment is helpful for systolic pressure control in patients with essential hypertension but is meaningless for diastolic pressure control.
