国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
17期
2282-2284
,共3页
袁俊菲%林杰%孔维菊%肖立%陈力平
袁俊菲%林傑%孔維菊%肖立%陳力平
원준비%림걸%공유국%초립%진력평
甲状腺功能减退%小而密低密度脂蛋白%甲状腺激素%动脉粥样硬化
甲狀腺功能減退%小而密低密度脂蛋白%甲狀腺激素%動脈粥樣硬化
갑상선공능감퇴%소이밀저밀도지단백%갑상선격소%동맥죽양경화
hypothroidism%small dense low-density lipoprotein%thyroid hormones%atherosclerosis
目的:研究不同程度原发性甲状腺功能减退患者血清小而密低密度脂蛋白胆固醇(sdLDL-C)水平的变化,探讨甲状腺功能减退时血清 sdLDL-C 水平变化的临床意义。方法选取临床性原发性甲状腺功能减退受试者60例(甲减组),亚临床性甲状腺功能减退受试者96例(亚甲减组)及甲状腺功能正常的受试者132例(正常组)。取空腹血检测 FT3、FT4、促甲状腺激素(TSH)、TG、TC、HDL-C、LDL-C、载脂蛋白 AⅠ(ApoAⅠ)、载脂蛋白 B(ApoB)及 sdLDL-C 水平。采用方差分析、Kruskal-Wallis H 检验及 Spearman 等级相关分析进行统计学分析。结果亚甲减组血清 sdLDL-C 水平显著高于正常组(t=5.78,P <0.01),甲减组血清 sdLDL-C 水平显著高于正常组(t=6.68,P <0.01)和亚甲减组(t =-2.88,P <0.01);组间差异有统计学意义(F =37.66,P <0.01)。相关性分析显示不同程度甲状腺功能减退患者 sdLDL-C 与经对数转换后的 TSH 浓度值(LgTSH)呈正相关(r=0.203,P =0.011),与 FT4呈负相关(r=-0.169,P =0.035)。结论 sdLDL-C 水平升高是原发性甲状腺功能减退患者血脂异常的表现之一,可能是甲状腺功能减退患者发生动脉粥样硬化的重要危险因素。
目的:研究不同程度原髮性甲狀腺功能減退患者血清小而密低密度脂蛋白膽固醇(sdLDL-C)水平的變化,探討甲狀腺功能減退時血清 sdLDL-C 水平變化的臨床意義。方法選取臨床性原髮性甲狀腺功能減退受試者60例(甲減組),亞臨床性甲狀腺功能減退受試者96例(亞甲減組)及甲狀腺功能正常的受試者132例(正常組)。取空腹血檢測 FT3、FT4、促甲狀腺激素(TSH)、TG、TC、HDL-C、LDL-C、載脂蛋白 AⅠ(ApoAⅠ)、載脂蛋白 B(ApoB)及 sdLDL-C 水平。採用方差分析、Kruskal-Wallis H 檢驗及 Spearman 等級相關分析進行統計學分析。結果亞甲減組血清 sdLDL-C 水平顯著高于正常組(t=5.78,P <0.01),甲減組血清 sdLDL-C 水平顯著高于正常組(t=6.68,P <0.01)和亞甲減組(t =-2.88,P <0.01);組間差異有統計學意義(F =37.66,P <0.01)。相關性分析顯示不同程度甲狀腺功能減退患者 sdLDL-C 與經對數轉換後的 TSH 濃度值(LgTSH)呈正相關(r=0.203,P =0.011),與 FT4呈負相關(r=-0.169,P =0.035)。結論 sdLDL-C 水平升高是原髮性甲狀腺功能減退患者血脂異常的錶現之一,可能是甲狀腺功能減退患者髮生動脈粥樣硬化的重要危險因素。
목적:연구불동정도원발성갑상선공능감퇴환자혈청소이밀저밀도지단백담고순(sdLDL-C)수평적변화,탐토갑상선공능감퇴시혈청 sdLDL-C 수평변화적림상의의。방법선취림상성원발성갑상선공능감퇴수시자60례(갑감조),아림상성갑상선공능감퇴수시자96례(아갑감조)급갑상선공능정상적수시자132례(정상조)。취공복혈검측 FT3、FT4、촉갑상선격소(TSH)、TG、TC、HDL-C、LDL-C、재지단백 AⅠ(ApoAⅠ)、재지단백 B(ApoB)급 sdLDL-C 수평。채용방차분석、Kruskal-Wallis H 검험급 Spearman 등급상관분석진행통계학분석。결과아갑감조혈청 sdLDL-C 수평현저고우정상조(t=5.78,P <0.01),갑감조혈청 sdLDL-C 수평현저고우정상조(t=6.68,P <0.01)화아갑감조(t =-2.88,P <0.01);조간차이유통계학의의(F =37.66,P <0.01)。상관성분석현시불동정도갑상선공능감퇴환자 sdLDL-C 여경대수전환후적 TSH 농도치(LgTSH)정정상관(r=0.203,P =0.011),여 FT4정부상관(r=-0.169,P =0.035)。결론 sdLDL-C 수평승고시원발성갑상선공능감퇴환자혈지이상적표현지일,가능시갑상선공능감퇴환자발생동맥죽양경화적중요위험인소。
Objective To study the serum small dense low density lipoprotein-cholesterol (sdLDL-C)concentration in patients with clinical and sub-clinical primary hypothyroidism,and to explore the clinical significance of serum sdLDL-C determination in pa-tients with hypothyroidism.Methods 60 patients with clinical hypothyroidism(clinical hypothyroidism group),96 cases with sub-clinical hypothyroidism(sub-clinical hypothyroidism group)and 132 normal subjects (normal group)were enrolled in the study. FT3,FT4,thyroid stimulating hormone (TSH),TG,TC,HDL-C,LDL-C,apolipoprotein AⅠ(ApoAⅠ),apolipoprotein B (ApoB), and sdLDL-C concentrations were measured.Analysis of Variance,Kruskal-Wallis H test and Spearman rank correlation analysis were used for statistical analysis.Results The concentration of sdLDL-C in sub-clinical hypothyroidism group was significantly higher than that in normal group (t=5.78,P <0.01),the concentration of sdLDL-C in clinical hypothyroidism group was signifi-cantly higher than that in sub-clinical hypothyroidism group(t=-2.88,P <0.01)and in normal group (t=6.68,P <0.01).There was statistically significant difference among groups (F =37.66,P <0.01).Correlation analysis showed that sdLDL-C in primary hypothyroidism patients was positively correlated with LgTSH (r =0.203,P =0.011 ),and negatively correlated with FT4 (r =-0.169,P =0.035).Conclusion The high concentration of sdLDL-C is a manifestation of dyslipidemia in primary hypothyroidism patients,and an important risk factor for atherosclerosis in primary hypothyroidism patients.