CAJ | 학술논문

目的：探讨瑞舒伐他汀对高脂诱导肥胖大鼠的血脂及白介素-6（IL-6）水平的影响。方法将30只雄性大鼠随机分成肥胖组（n=20）和对照组（n=10），分别用高脂饲料和普通饲料饲养14周，然后根据体重增加程度筛选出肥胖大鼠，并分别测定血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL- C）、低密度脂蛋白胆固醇（LDL- C）和IL-6的水平。对肥胖组进行瑞舒伐他汀干预，比较其干预前后血脂及IL-6的水平。结果肥胖组大鼠血清TG、TC、LDL- C和IL-6水平均显著高于对照组（均P＜0.01），血清IL-6水平与TC、LDL- C呈显著正相关（r=0.72、0.71，均P＜0.01）；瑞舒伐他汀显著降低肥胖大鼠的血脂及IL-6水平。结论高脂诱导的肥胖大鼠血清IL-6明显升高，瑞舒伐他汀降低血脂的同时，能降低炎症因子IL-6的水平。
목적：탐토서서벌타정대고지유도비반대서적혈지급백개소-6（IL-6）수평적영향。방법장30지웅성대서수궤분성비반조（n=20）화대조조（n=10），분별용고지사료화보통사료사양14주，연후근거체중증가정도사선출비반대서，병분별측정혈청총담고순（TC）、감유삼지（TG）、고밀도지단백담고순（HDL- C）、저밀도지단백담고순（LDL- C）화IL-6적수평。대비반조진행서서벌타정간예，비교기간예전후혈지급IL-6적수평。결과비반조대서혈청TG、TC、LDL- C화IL-6수평균현저고우대조조（균P＜0.01），혈청IL-6수평여TC、LDL- C정현저정상관（r=0.72、0.71，균P＜0.01）；서서벌타정현저강저비반대서적혈지급IL-6수평。결론고지유도적비반대서혈청IL-6명현승고，서서벌타정강저혈지적동시，능강저염증인자IL-6적수평。
Objective To evaluate the effects of Rosuvastatin on serum IL- 6 and lipid in high- fat diet- induced obese rats. Methods Thirty male rats were divided into obese(n=20) and control(n=10)groups randomly, and fed a high- fat diet and a standard diet,respectively,for 14 weeks. Obesity was determined based on body weight increment. Serum TC、TG、HDL- C 、LDL- C and IL- 6 were measured. Obese rats were treated with Rosuvastatin. Serum lipid and IL- 6 were compared before and after treatment of Rosuvastatin. Results The levels of serum TG, TC, LDL- C and IL- 6 were significantly higher in obese group than those in the control group(P<0.01) .The level of IL- 6 was significantly correlated with TC and LDL- C levels (r=0.72、0.71, P<0.01). Rosuvastatin significantly decreased serum lipid and IL- 6 of obese rats. Conclusion Serum IL- 6 increases obviously in high- fat diet- induced obese rats. Rosuvastatin could reduce serum IL- 6 as wel as lipid.