CAJ | 학술논문

目的：探讨不同性别初发2型糖尿病患者中血尿酸与空腹血糖的相关性。方法对初发2型糖尿病患者282例(男性208例,女性74例)检测空腹血糖、血尿酸、肌酐、转氨酶、血脂等血清学指标。根据空腹血糖水平分为3组：<7.0 mmol/L为118例(男性89例、女性29例)、7.0~9.0 mmol/L为114例(男性88例、女性26例)、>9.0 mmol/L为50例(男性31例、女性19例)。结果(1)初发2型糖尿病患者中不同性别血尿酸水平差异有统计学意义[男性(325.82±92.26)μmol/L,女性(292.26±76.19)μmol/L, P<0.01]；(2)所有患者中空腹血糖与血尿酸水平呈负相关(r=-0.316, P<0.01),余临床资料无明显相关性；(3)男性空腹血糖与血尿酸水平呈负相关(r=-0.320, P<0.01),女性空腹血糖与血尿酸水平呈负相关(r=-0.291, P<0.05)；(4)多元逐步回归分析显示,男性、女性各分组空腹血糖与血尿酸水平均有回归关系(均P<0.01)。结论无论男女性,在初发2型糖尿病患者中随着空腹血糖的升高血尿酸水平是降低的,因此,血尿酸水平可以作为反映葡萄糖代谢的一个潜在的生物标志物。
목적：탐토불동성별초발2형당뇨병환자중혈뇨산여공복혈당적상관성。방법대초발2형당뇨병환자282례(남성208례,녀성74례)검측공복혈당、혈뇨산、기항、전안매、혈지등혈청학지표。근거공복혈당수평분위3조：<7.0 mmol/L위118례(남성89례、녀성29례)、7.0~9.0 mmol/L위114례(남성88례、녀성26례)、>9.0 mmol/L위50례(남성31례、녀성19례)。결과(1)초발2형당뇨병환자중불동성별혈뇨산수평차이유통계학의의[남성(325.82±92.26)μmol/L,녀성(292.26±76.19)μmol/L, P<0.01]；(2)소유환자중공복혈당여혈뇨산수평정부상관(r=-0.316, P<0.01),여림상자료무명현상관성；(3)남성공복혈당여혈뇨산수평정부상관(r=-0.320, P<0.01),녀성공복혈당여혈뇨산수평정부상관(r=-0.291, P<0.05)；(4)다원축보회귀분석현시,남성、녀성각분조공복혈당여혈뇨산수평균유회귀관계(균P<0.01)。결론무론남녀성,재초발2형당뇨병환자중수착공복혈당적승고혈뇨산수평시강저적,인차,혈뇨산수평가이작위반영포도당대사적일개잠재적생물표지물。
Objective To explore the relationship between serum uric acid and fasting blood glucose ( FBG) in newly-diagnosed type 2 diabetes in regard to different genders. Methods In 282 patients of newly diagnosed type 2 diabetes(208 males and 74 females), detection of serum FBG, uric acid, creatinine, transaminases, blood lipids, etc were determined. FBG<7. 0 mmol/L was found in 118 cases (89 males and 29 females);7. 0 mmol/L≤FBG≤9. 0 mmol/L in 114 cases ( 88 males and 26 females ); FBG>9. 0 mmol/L in 50 cases ( 31 males and 19 females). Results (1)Serum uric acid showed statistically significant difference in regard to sex[Male:(325. 82±92. 26)μmol/L, Female:(292. 26±76. 19)μmol/L, P<0. 01]. (2) FBG and serum uric acid were negatively related(r=-0. 316, P<0. 01). (3) FBG and serum uric acid were negatively related both in male(r=-0. 320, P<0.01)andinfemale(r=-0.291,P<0.05). (4)Multiplestepwiseregressionanalysisshowedthatthethreegroups of FBG and serum uric acid showed regression relationship in male and female patients(P<0. 01). Conclusion With the increased FBG, serum uric acid was decreased in both males and females. Therefore, serum uric acid might serve as a potential biomarker of glucose metabolism.