CAJ | 학술논문

目的：观察急性脑梗死后血清白细胞介素6（IL-6）与神经功能缺损程度评分的动态变化，探讨IL-6对急性脑梗死后神经功能恢复的影响及β-七叶皂甙钠治疗急性脑梗死的作用机制。方法选择急性脑梗死患者63例，随机分为对照组30例和治疗组33例，对照组予以脑梗死常规治疗，治疗组在常规治疗基础上加用β-七叶皂甙钠，在脑梗死后1、5、14d进行血清IL-6测定和美国国立卫生研究院卒中量表（NIHSS）评分。另选取健康体检者30例为正常组，清晨测定血清IL-6。结果治疗组和对照组患者脑梗死后1、5、14dIL-6水平较正常组明显升高，差异有统计学意义（P＜0．01）；治疗组脑梗死后14d血清IL-6水平明显低于对照组[（13．33±2．82ng/L）vs（15．25±4.65）ng/L，P＜0．05]；对照组和治疗组脑梗死后14d神经功能缺损评分较1、5d明显改善，差异有统计学意义（P＜0.01）；治疗组脑梗死后14d神经功能缺损评分较对照组明显降低[（9．03±2．28）分vs（10．38±2．30）分，P＜0．05]；脑梗死患者血清IL-6水平与神经功能缺损评分呈正相关（r＝0．888，P＜0．01）。结论急性脑梗死后血清IL-6水平与神经功能缺损密切相关，β-七叶皂甙钠可能通过抑制血清IL-6的增高而改善神经功能。
목적：관찰급성뇌경사후혈청백세포개소6（IL-6）여신경공능결손정도평분적동태변화，탐토IL-6대급성뇌경사후신경공능회복적영향급β-칠협조대납치료급성뇌경사적작용궤제。방법선택급성뇌경사환자63례，수궤분위대조조30례화치료조33례，대조조여이뇌경사상규치료，치료조재상규치료기출상가용β-칠협조대납，재뇌경사후1、5、14d진행혈청IL-6측정화미국국립위생연구원졸중량표（NIHSS）평분。령선취건강체검자30례위정상조，청신측정혈청IL-6。결과치료조화대조조환자뇌경사후1、5、14dIL-6수평교정상조명현승고，차이유통계학의의（P＜0．01）；치료조뇌경사후14d혈청IL-6수평명현저우대조조[（13．33±2．82ng/L）vs（15．25±4.65）ng/L，P＜0．05]；대조조화치료조뇌경사후14d신경공능결손평분교1、5d명현개선，차이유통계학의의（P＜0.01）；치료조뇌경사후14d신경공능결손평분교대조조명현강저[（9．03±2．28）분vs（10．38±2．30）분，P＜0．05]；뇌경사환자혈청IL-6수평여신경공능결손평분정정상관（r＝0．888，P＜0．01）。결론급성뇌경사후혈청IL-6수평여신경공능결손밀절상관，β-칠협조대납가능통과억제혈청IL-6적증고이개선신경공능。
Objective To study the association between serum IL-6 level and nerve function score and the effect of β-aescinum natrium on AIS by observing their dynamic changes in AIS patients . Methods Sixty-three AIS patients were randomly divided into control group (n=30) and treat-ment group (n=33) .Patients in control group received routine treatment and those in treatment group underwent combined routine and β-aescinum natrium treatment .Their serum IL-6 level was measured on days 1 ,5 and 14 after ischemic stroke and their nerve function was scored at the cor-responding time points .Thirty healthy subjects undergoing physical examination served as a nor-mal group and their serum IL-6 level was measured at morning .Results The serum IL-6 level was significantly higher in treatment group and control group than in normal group on days 1 ,5 and 14 after ischemic stroke ,and significantly lower in treatment group than in control group on day 14 after ischemic stroke (13 .33 ± 2 .82 ng/L vs 15 .25 ± 4 .65 ng/L ,P<0 .05) .The NIHSS score of nerve function was higher in treatment group and control group on day 14 than on days 1 and 5 after ischemic stroke (P<0 .01) ,and significantly lower in treatment group than in control group on day 14 after ischemic stroke (9 .03 ± 2 .28 vs 10 .38 ± 2 .30 ,P<0 .05) .The serum IL-6 level was positively related with the NIHSS score of nerve function in AIS patients (r=0 .888 , P<0 .01) .Conclusion The serum IL-6 level is closely associated with the nerve function score andβ-aescinum improves the nerve function by reducing the serum IL-6 level in AIS patients .