中华老年心脑血管病杂志
中華老年心腦血管病雜誌
중화노년심뇌혈관병잡지
CHINESE JOURNAL OF GERIATRIC CARDIOVASCULAR AND CEREBROVASCULAR DISEASES
2014年
8期
826-829
,共4页
苏江利%刘玉%夏章勇%杨霞峰%曲怀谦%薛新红
囌江利%劉玉%夏章勇%楊霞峰%麯懷謙%薛新紅
소강리%류옥%하장용%양하봉%곡부겸%설신홍
脑梗死%胆红素%P选择素%C反应蛋白质%早期诊断
腦梗死%膽紅素%P選擇素%C反應蛋白質%早期診斷
뇌경사%담홍소%P선택소%C반응단백질%조기진단
brain infarction%bilirubin%P-selectin%C-reactive protein%early diagnosis
目的：探讨急性老年脑梗死患者血清P选择素和胆红素在不同时间、不同病情的动态变化及其临床意义。方法选择脑梗死患者98例（脑梗死组），据据神经功能缺损程度分为轻型38例、中型35例、重型25例，另选取健康体检者30例为对照组，测定脑梗死组患者发病1、3、7、14d和对照组血清可溶性P选择素和胆红素及高敏C反应蛋白水平的动态变化。结果脑梗死组1、3、7dP选择素、高敏C反应蛋白、总胆红素和间接胆红素明显高于对照组，差异有统计学意义（P＜0．05）。与脑梗死轻型患者比较，中型和重型患者1、3、7dP选择素显著升高[（78．2±15．0）ng/L，（107．1±24．3）ng/L，（91．5±21．1）ng/L和（85．5±18．5）ng/L，（135．2±34．0）ng/L，（99．3±27．0）ng/Lvs（48．8±6．7）ng/L，（86．0±10．9）ng/L，（72．5±11．3）ng/L，P＜0．05]。结论P选择素和胆红素可能参与脑梗死的病理过程，测定P选择素和胆红素有利于脑梗死的早期诊治及判断预后。
目的：探討急性老年腦梗死患者血清P選擇素和膽紅素在不同時間、不同病情的動態變化及其臨床意義。方法選擇腦梗死患者98例（腦梗死組），據據神經功能缺損程度分為輕型38例、中型35例、重型25例，另選取健康體檢者30例為對照組，測定腦梗死組患者髮病1、3、7、14d和對照組血清可溶性P選擇素和膽紅素及高敏C反應蛋白水平的動態變化。結果腦梗死組1、3、7dP選擇素、高敏C反應蛋白、總膽紅素和間接膽紅素明顯高于對照組，差異有統計學意義（P＜0．05）。與腦梗死輕型患者比較，中型和重型患者1、3、7dP選擇素顯著升高[（78．2±15．0）ng/L，（107．1±24．3）ng/L，（91．5±21．1）ng/L和（85．5±18．5）ng/L，（135．2±34．0）ng/L，（99．3±27．0）ng/Lvs（48．8±6．7）ng/L，（86．0±10．9）ng/L，（72．5±11．3）ng/L，P＜0．05]。結論P選擇素和膽紅素可能參與腦梗死的病理過程，測定P選擇素和膽紅素有利于腦梗死的早期診治及判斷預後。
목적：탐토급성노년뇌경사환자혈청P선택소화담홍소재불동시간、불동병정적동태변화급기림상의의。방법선택뇌경사환자98례（뇌경사조），거거신경공능결손정도분위경형38례、중형35례、중형25례，령선취건강체검자30례위대조조，측정뇌경사조환자발병1、3、7、14d화대조조혈청가용성P선택소화담홍소급고민C반응단백수평적동태변화。결과뇌경사조1、3、7dP선택소、고민C반응단백、총담홍소화간접담홍소명현고우대조조，차이유통계학의의（P＜0．05）。여뇌경사경형환자비교，중형화중형환자1、3、7dP선택소현저승고[（78．2±15．0）ng/L，（107．1±24．3）ng/L，（91．5±21．1）ng/L화（85．5±18．5）ng/L，（135．2±34．0）ng/L，（99．3±27．0）ng/Lvs（48．8±6．7）ng/L，（86．0±10．9）ng/L，（72．5±11．3）ng/L，P＜0．05]。결론P선택소화담홍소가능삼여뇌경사적병리과정，측정P선택소화담홍소유리우뇌경사적조기진치급판단예후。
Objective To study the dynamic change of bilirubin and P-selectin in elderly acute is-chemic stroke (AIS) patients at different time points and at different conditions of disease and its clinical significance .Methods Ninety-eight ischemic stroke (IS)patients were divided into mild IS group (n=38) ,moderate IS group (n=35) and severe IS group (n=25) according to their nerve function score ,and 30 healthy subjects undergoing physical examination served as a control group .Their serum levels of P-selectin ,bilirubin and hs-CRP were measured on days 1 ,3 ,7 and 14 respectively after onset of IS .Results The serum levels of P-selectin ,hs-CRP ,total and indirect bilirubin were significantly higher in different IS groups than in control group ,in moderate and se-vere IS groups than in mild IS group on days 1 ,3 ,7 after onset of IS (P<0 .05) .The serum P-se-lectin level was significantly higher in moderate and severe IS groups than in control group on day 14 after onset of IS (78 .2 ± 15 .0 ng/L ,107 .1 ± 24 .3 ng/L ,91 .5 ± 21 .1 ng/L ,85 .5 ± 18 .5 ng/L , 135.2±34.0ng/L,99.3±27.0ng/L vs48.8±6.7ng/L,86.0±10.9ng/L,72.5±11.3ng/L, P<0 .05) .Conclusion P-selectin and bilirubin may be involved in the pathogenesis of IS .Meas-urement of serum P-selectin and bilirubin level contributes to the early diagnosis and treatment of IS and assessment of its prognosis .
