中华老年心脑血管病杂志
中華老年心腦血管病雜誌
중화노년심뇌혈관병잡지
CHINESE JOURNAL OF GERIATRIC CARDIOVASCULAR AND CEREBROVASCULAR DISEASES
2014年
8期
800-804
,共5页
张少景%王青%徐颖%赵清华%吴薇
張少景%王青%徐穎%趙清華%吳薇
장소경%왕청%서영%조청화%오미
肌钙蛋白T%急性冠状动脉综合征%心肌缺血%糖尿病%C反应蛋白质%肾小球滤过率
肌鈣蛋白T%急性冠狀動脈綜閤徵%心肌缺血%糖尿病%C反應蛋白質%腎小毬濾過率
기개단백T%급성관상동맥종합정%심기결혈%당뇨병%C반응단백질%신소구려과솔
troponin T%acute coronary syndrome%myocardial ischemia%diabetes mellitus%C-reac-tive protein%glomerular filtration rate
目的:了解住院老年患者高敏肌钙蛋白T (hs-cT nT )水平,分析影响hs-cT nT水平的非缺血因素。方法选择老年无急性冠状动脉综合征住院患者670例,按hs-cT nT 3分位水平将患者分为低值组232例、中值组237例和高值组201例,检测hs-cTnT ,收集一般资料、N末端B型钠尿肽前体(NT-proBNP)等指标及超声心动图等。结果与低值组和中值组比较,高值组患者男性、糖尿病、慢性肾病、室壁运动异常、年龄、心率、lg白细胞、lg高敏C反应蛋白、lgNT-proBNP、左心室质量指数(LVMI)等明显升高(P<0.05,P<0.01),估算肾小球滤过率(eGFR)、LVEF明显降低(P<0.01)。Spearman分析显示,hs-cTnT 与男性(r=0.225,P=0.000)、年龄(r=0.338,P=0.000)、lgNT-proBNP(r=0.394,P=0.000)、eGFR(r=-0.253,P=0.000)、糖尿病(r=0.138,P=0.001)、LVMI(r=0.186,P=0.000)、LVEF(r=-0.261,P=0.000)和心率(r=0.081,P=0.036)相关。结论老年无急性冠状动脉综合征住院患者存在低水平hs-cTnT升高,hs-cTnT 与男性、年龄、NT-proBNP、eGFR、糖尿病、LVMI、LVEF及心率相关,提示低水平hs-cT nT升高患者可能预后不佳。
目的:瞭解住院老年患者高敏肌鈣蛋白T (hs-cT nT )水平,分析影響hs-cT nT水平的非缺血因素。方法選擇老年無急性冠狀動脈綜閤徵住院患者670例,按hs-cT nT 3分位水平將患者分為低值組232例、中值組237例和高值組201例,檢測hs-cTnT ,收集一般資料、N末耑B型鈉尿肽前體(NT-proBNP)等指標及超聲心動圖等。結果與低值組和中值組比較,高值組患者男性、糖尿病、慢性腎病、室壁運動異常、年齡、心率、lg白細胞、lg高敏C反應蛋白、lgNT-proBNP、左心室質量指數(LVMI)等明顯升高(P<0.05,P<0.01),估算腎小毬濾過率(eGFR)、LVEF明顯降低(P<0.01)。Spearman分析顯示,hs-cTnT 與男性(r=0.225,P=0.000)、年齡(r=0.338,P=0.000)、lgNT-proBNP(r=0.394,P=0.000)、eGFR(r=-0.253,P=0.000)、糖尿病(r=0.138,P=0.001)、LVMI(r=0.186,P=0.000)、LVEF(r=-0.261,P=0.000)和心率(r=0.081,P=0.036)相關。結論老年無急性冠狀動脈綜閤徵住院患者存在低水平hs-cTnT升高,hs-cTnT 與男性、年齡、NT-proBNP、eGFR、糖尿病、LVMI、LVEF及心率相關,提示低水平hs-cT nT升高患者可能預後不佳。
목적:료해주원노년환자고민기개단백T (hs-cT nT )수평,분석영향hs-cT nT수평적비결혈인소。방법선택노년무급성관상동맥종합정주원환자670례,안hs-cT nT 3분위수평장환자분위저치조232례、중치조237례화고치조201례,검측hs-cTnT ,수집일반자료、N말단B형납뇨태전체(NT-proBNP)등지표급초성심동도등。결과여저치조화중치조비교,고치조환자남성、당뇨병、만성신병、실벽운동이상、년령、심솔、lg백세포、lg고민C반응단백、lgNT-proBNP、좌심실질량지수(LVMI)등명현승고(P<0.05,P<0.01),고산신소구려과솔(eGFR)、LVEF명현강저(P<0.01)。Spearman분석현시,hs-cTnT 여남성(r=0.225,P=0.000)、년령(r=0.338,P=0.000)、lgNT-proBNP(r=0.394,P=0.000)、eGFR(r=-0.253,P=0.000)、당뇨병(r=0.138,P=0.001)、LVMI(r=0.186,P=0.000)、LVEF(r=-0.261,P=0.000)화심솔(r=0.081,P=0.036)상관。결론노년무급성관상동맥종합정주원환자존재저수평hs-cTnT승고,hs-cTnT 여남성、년령、NT-proBNP、eGFR、당뇨병、LVMI、LVEF급심솔상관,제시저수평hs-cT nT승고환자가능예후불가。
Objective To analyze the effect of non-ischemic factors on hs-cTnT in elderly hospital-ized patients .Methods Six hundred and seventy elderly hospitalized patients without acute coro-nary syndrome were divided into low hs-cTnT group (n= 232) ,moderate hs-cTnT group (n=237) and high hs-cTnT group (n = 201) .The patients underwent echocardiography .Their hs-cTnT and NT-proBNP levels were measured .Results The incidence of diabetes mellitus and chronic kidney disease ,abnormal ventricular wall motion ,age ,heart rate ,WBC ,serum hs-CRP and NT-proBNP level ,and LVMI were significantly higher while the eGFR and LVEF were signifi-cantly lower in low hs-cTnT group than in moderate hs-cTnT group (P< 0 .05 ,P< 0 .01) . Spearman analysis showed that the hs-cTnT level was related with gender (r=0.225) ,age (r=0.338) ,lgNT-proBNP (r=0 .394) ,eGFR (r= -0 .253) ,diabetes mellitus (r=0.138) ,LVMI (r=0 .186) ,LVEF (r= -0 .261) and heart rate (r= 0 .081 ,P<0 .05 ,P< 0 .01) .Conclusion The hs-cTnT level is slightly higher in elderly hospitalized patients without acute coronary syndrome and is related with gender ,age ,NT-proBNP ,eGFR ,diabetes mellitus ,LVMI ,LVEF and heart rate ,indicating that the prognosis of elderly hospitalized patients without acute coronary syn-drome is poor .