CAJ | 학술논문

目的：探讨乳腺神经内分泌癌的超声表现及病理特点。方法分析4例乳腺神经内分泌癌患者的临床资料、超声表现、病理及免疫组化结果。结果乳腺肿块2例位于右侧，2例位于左侧；4例均为不均匀低回声，2例表现为斑点状钙化，3例血流信号丰富。免疫组化检查，均表达嗜铬颗粒蛋白A（CgA）、神经元特异性烯醇化酶（NSE），3例表达突触素（Syn）。随访期间未见复发。结论乳腺神经内分泌癌是一种罕见的乳腺恶性肿瘤，超声表现有一定特征，雌孕激素受体阳性与CerbB-2基因表达阴性是预后良好的指标，确诊主要依靠病理组织学检查及免疫组化染色。
목적：탐토유선신경내분비암적초성표현급병리특점。방법분석4례유선신경내분비암환자적림상자료、초성표현、병리급면역조화결과。결과유선종괴2례위우우측，2례위우좌측；4례균위불균균저회성，2례표현위반점상개화，3례혈류신호봉부。면역조화검사，균표체기락과립단백A（CgA）、신경원특이성희순화매（NSE），3례표체돌촉소（Syn）。수방기간미견복발。결론유선신경내분비암시일충한견적유선악성종류，초성표현유일정특정，자잉격소수체양성여CerbB-2기인표체음성시예후량호적지표，학진주요의고병리조직학검사급면역조화염색。
Objective To investigate the ultrasonographic features of breast neuroendocrine carcinoma as well as its clinical and histopathological characteristics. Methods The clinical data,ultrasonographic features,pathological and immunohistochemical results of four patients with breast neuroendocrine cancer were analyzed. Results The masses of 2 patients located in the right breast,the other two were in the left side. Among all the 4 cases,masses showed uneven low echo,2 of them presented punctate calcification,3 showed rich blood flow. Results In histopathological examination,the CgA and NSE were expressed in all cases and Syn was expressed in 3 cases. During the follow-up period,no recurrence was found. Conclusion Breast neuroendocrine carcinoma is a kind of rare breast malignancy. It has a certain ultrasonographic features. The positive estrogen and progesterone receptor and CerbB-2 gene expression are indicators for the good prognosis. The diagnosis of breast neuroendocrine carcinoma mainly relies on histopathological examination and immunohistochemical staining.