CAJ | 학술논문

【目的】观察依帕司他联合前列地尔治疗糖尿病周围神经病变（DPN ）的临床疗效。【方法】将88例2型糖尿病（T2DM ）DPN的患者随机分为对照组与观察组，各44例，两组患者均严格控制饮食、适量运动、口服降糖药或注射胰岛素控制血糖，甲钴胺注射液0．5 mg肌注，每日1次。在此基础上，观察组加用依帕司他50 mg口服，每日3次；前列地尔20μg＋0．9％氯化钠注射液100 m L静脉滴注，每日1次。疗程均为2周。【结果】观察组患者自觉症状改善总有效率（97．7％）显著高于对照组（72．7％）（ P ＜0．05）；两组神经传导速度（NCV）均明显改善，观察组优于对照组，差异具有统计学意义（ P ＜0．01）。【结论】依帕司他、前列地尔及甲钴胺注射液联合治疗DPN效果显著。
【목적】관찰의파사타연합전렬지이치료당뇨병주위신경병변（DPN ）적림상료효。【방법】장88례2형당뇨병（T2DM ）DPN적환자수궤분위대조조여관찰조，각44례，량조환자균엄격공제음식、괄량운동、구복강당약혹주사이도소공제혈당，갑고알주사액0．5 mg기주，매일1차。재차기출상，관찰조가용의파사타50 mg구복，매일3차；전렬지이20μg＋0．9％록화납주사액100 m L정맥적주，매일1차。료정균위2주。【결과】관찰조환자자각증상개선총유효솔（97．7％）현저고우대조조（72．7％）（ P ＜0．05）；량조신경전도속도（NCV）균명현개선，관찰조우우대조조，차이구유통계학의의（ P ＜0．01）。【결론】의파사타、전렬지이급갑고알주사액연합치료DPN효과현저。
To observe clinical efficacy of epalrestat combined with alprostadil for the treatment of diabetic perineuropathy(DPN) .[Methods] Totally 88 patients with type 2 diabetes mellitus(T2DM) peripheral neuropathy were randomly divided into control group ( n =44) and observation group( n = 44) .Patients in two groups received strict diet control ,appropriate exercise ,oral blood glucose lowering drug or insulin injection to control blood glucose ,and also intramuscular injection with mecobalamin 0 .5mg once daily .On the basis of the treatment of the control group ,the observation group additionally received oral epalrestat 50mg 3 times per day and alprostadil 20 μg+ 0 .9% sodium chloride by intravenous injection once daily .The treatment course was 2 weeks .[Results] The total effective rate of the improvement of subjective symptoms in observation group (97 .7% ) was significantly higher than that in control group(72 .7% )( P<0 .05) .Motor nerve conduction velocity (MNCV) in two groups was obviously improved ,and the improvement in observation group was better than control group , and there was significant difference ( P < 0 .01) .[Conclusion] The combination of epalrestat ,alprostadil and mecobalamine injection is markedly effective in the treatment of DPN .