CAJ | 학술논문

甲状腺肿瘤/病理学%甲状腺肿瘤/代谢%甲状腺肿瘤/血液供给%阻遏蛋白质类/代谢%组蛋白脱乙酰基酶类/代谢%肿瘤浸润%肿瘤转移%新生血管化 ,病理性%免疫组织化学甲狀腺腫瘤/病理學%甲狀腺腫瘤/代謝%甲狀腺腫瘤/血液供給%阻遏蛋白質類/代謝%組蛋白脫乙酰基酶類/代謝%腫瘤浸潤%腫瘤轉移%新生血管化 ,病理性%免疫組織化學
갑상선종류/병이학%갑상선종류/대사%갑상선종류/혈액공급%조알단백질류/대사%조단백탈을선기매류/대사%종류침윤%종류전이%신생혈관화 ,병이성%면역조직화학
Thyroid Neoplasms/PA%Thyroid Neoplasms/ME%Thyroid Neoplasms/BS%Repress-or Proteins/ME%Histone Deacetylases/ME%Neoplasm Invasiveness%Neoplasm Me-tastasis%Neovascularization,Pathologic%Immunohistochemistry

【目的】探讨转移相关基因（M t a-1）蛋白在甲状腺肿瘤组织中的表达及其与肿瘤血管生成的关系。【方法】选择甲状腺肿瘤石蜡组织标本160例，其中甲状腺癌120例和甲状腺腺瘤40例，另选择正常甲状腺组织50例。采用免疫组织化学SP法检测上述标本中M ta-1蛋白的表达，并检测其肿瘤微血管计数（M VC ），分析M ta-1蛋白的表达与肿瘤血管生成的关系。【结果】甲状腺癌中M ta-1阳性表达和M VC值明显高于正常甲状腺组织和甲状腺腺瘤，其差异有统计学意义（ P ＜0．05）。在120例甲状腺癌组织中，M ta-1的阳性表达和MVC值均与是否有颈部淋巴结转移、包膜完整性及 TNM 分期密切相关（ P ＜0．01），而与其他临床病理特征指标无关（ P ＞0．05）。甲状腺癌组织中 M ta-1表达与 M VC 值呈正相关（ r ＝0．625， P ＜0．01）。【结论】M ta-1蛋白的异常表达与甲状腺癌的发生、浸润、淋巴转移等恶性潜能密切相关，其参与了甲状腺癌组织中肿瘤新生血管的生成。
【목적】탐토전이상관기인（M t a-1）단백재갑상선종류조직중적표체급기여종류혈관생성적관계。【방법】선택갑상선종류석사조직표본160례，기중갑상선암120례화갑상선선류40례，령선택정상갑상선조직50례。채용면역조직화학SP법검측상술표본중M ta-1단백적표체，병검측기종류미혈관계수（M VC ），분석M ta-1단백적표체여종류혈관생성적관계。【결과】갑상선암중M ta-1양성표체화M VC치명현고우정상갑상선조직화갑상선선류，기차이유통계학의의（ P ＜0．05）。재120례갑상선암조직중，M ta-1적양성표체화MVC치균여시부유경부림파결전이、포막완정성급 TNM 분기밀절상관（ P ＜0．01），이여기타림상병리특정지표무관（ P ＞0．05）。갑상선암조직중 M ta-1표체여 M VC 치정정상관（ r ＝0．625， P ＜0．01）。【결론】M ta-1단백적이상표체여갑상선암적발생、침윤、림파전이등악성잠능밀절상관，기삼여료갑상선암조직중종류신생혈관적생성。
To explore the expression of metastasis associated gene (Mta-1) in thyroid tumor and its correlation with tumor angiogenesis .[Methods] Paraffin-embedded tissue samples from 160 cases of thyroid tumor were selected .Among them ,120 cases were thyroid cancer and 40 cases were thyroid adenoma .Other 50 cases of normal thyroid tissue were selected .The expression of Mta-1 and microvessel count (MVC) were detected by using immunohistochemical SP method .The correlation between Mta-1 and tumor angiogenesis was analyzed .[Results]The positive expression rate of Mta-1 and MVD value in thyroid cancer were obviously higher than those in normal thyroid and thyroid adenoma ,and there was significant difference( P<0 .05) .The positive expression of Mta-1 and MVD in 120 cases of thyroid cancer were closely related to lymph node metastasis ,peplos integrity and TNM stage ( P <0 .05) ,but not related to other clinicopathological indicators ( P > 0 .05) .There was positive correlation between Mta-1 expression and MVD( r =0 .625 ,P < 0 .01) .[Conclusion]Abnormal expression of Mta-1 is closely related with the occurrence ,infiltration ,lymph node metastasis and other malignant potentials of thyroid cancer ,and may in-volve in tumor neo-angiogenesis of thyroid cancer .