河北医科大学学报
河北醫科大學學報
하북의과대학학보
JOURNAL OF HEBEI MEDICAL UNIVERSITY
2014年
8期
904-907
,共4页
高建军%索晓慧%张燕%朱晓林%刘冬青%袁虎方
高建軍%索曉慧%張燕%硃曉林%劉鼕青%袁虎方
고건군%색효혜%장연%주효림%류동청%원호방
结直肠肿瘤%癌胚抗原%糖链抗原 19-9%C 反应蛋白质
結直腸腫瘤%癌胚抗原%糖鏈抗原 19-9%C 反應蛋白質
결직장종류%암배항원%당련항원 19-9%C 반응단백질
colorectal neoplasms%carcinoembryonic antigen%carbohydrate antigen 19-9(CA19-9)%C-reactive protein
目的：探讨联合检测血清癌胚抗原（carcinoembryonicantigen，CEA）、糖链抗原19-9（carbohyrate antigan 19-9，CA19-9）和炎症标志物 C 反应蛋白（C-reaction protein，CRP）对大肠癌诊断的临床应用价值。方法分别检测146例大肠癌患者、158例阑尾炎和结肠息肉患者、76例健康者 CEA、CA19-9、CRP 水平，并应用受试者工作特征（receive operating characteristic，ROC）曲线进行评价。结果与正常对照组比较，大肠癌组和良性炎症组血清 CRP、CEA 和 CA19-9水平均升高，大肠癌组 CRP 显著低于良性炎症组，但大肠癌组 CEA、CA19-9明显高于良性炎症组和正常对照组，差异有统计学意义（P ﹤0.01））。用 ROC 曲线比较 CEA、CA19-9和 CRP 区分良性炎症组和大肠癌的能力，显示 CRP 的诊断价值优于 CEA 和 CA19-9。利用 ROC 曲线分析联合检测三者的诊断能力，其 ROC 曲线下面积（area under the ROC curve，AUC）为0.886。结论联合检测 CEA、CA19-9和 CRP 可以弥补单项检测的不足，提高临床诊断的准确性，联合检测的准确性优于单项检测。
目的：探討聯閤檢測血清癌胚抗原（carcinoembryonicantigen，CEA）、糖鏈抗原19-9（carbohyrate antigan 19-9，CA19-9）和炎癥標誌物 C 反應蛋白（C-reaction protein，CRP）對大腸癌診斷的臨床應用價值。方法分彆檢測146例大腸癌患者、158例闌尾炎和結腸息肉患者、76例健康者 CEA、CA19-9、CRP 水平，併應用受試者工作特徵（receive operating characteristic，ROC）麯線進行評價。結果與正常對照組比較，大腸癌組和良性炎癥組血清 CRP、CEA 和 CA19-9水平均升高，大腸癌組 CRP 顯著低于良性炎癥組，但大腸癌組 CEA、CA19-9明顯高于良性炎癥組和正常對照組，差異有統計學意義（P ﹤0.01））。用 ROC 麯線比較 CEA、CA19-9和 CRP 區分良性炎癥組和大腸癌的能力，顯示 CRP 的診斷價值優于 CEA 和 CA19-9。利用 ROC 麯線分析聯閤檢測三者的診斷能力，其 ROC 麯線下麵積（area under the ROC curve，AUC）為0.886。結論聯閤檢測 CEA、CA19-9和 CRP 可以瀰補單項檢測的不足，提高臨床診斷的準確性，聯閤檢測的準確性優于單項檢測。
목적：탐토연합검측혈청암배항원（carcinoembryonicantigen，CEA）、당련항원19-9（carbohyrate antigan 19-9，CA19-9）화염증표지물 C 반응단백（C-reaction protein，CRP）대대장암진단적림상응용개치。방법분별검측146례대장암환자、158례란미염화결장식육환자、76례건강자 CEA、CA19-9、CRP 수평，병응용수시자공작특정（receive operating characteristic，ROC）곡선진행평개。결과여정상대조조비교，대장암조화량성염증조혈청 CRP、CEA 화 CA19-9수평균승고，대장암조 CRP 현저저우량성염증조，단대장암조 CEA、CA19-9명현고우량성염증조화정상대조조，차이유통계학의의（P ﹤0.01））。용 ROC 곡선비교 CEA、CA19-9화 CRP 구분량성염증조화대장암적능력，현시 CRP 적진단개치우우 CEA 화 CA19-9。이용 ROC 곡선분석연합검측삼자적진단능력，기 ROC 곡선하면적（area under the ROC curve，AUC）위0.886。결론연합검측 CEA、CA19-9화 CRP 가이미보단항검측적불족，제고림상진단적준학성，연합검측적준학성우우단항검측。
Objective To assess the diagnostic value of combined detection of tumor markers carcinoembryonic antigen( CEA),carbohyrate antigen 19-9( CA19-9 ) and inflammatory marker C reactive protein( CRP)in colon cancer. Methods Serum levels of CEA,CA199 and CA125 were determined in 146 patients with colorectal cancer,158 patients with inflammatory bowel disease,colon polyp or acute appendicitis,and 76 healthy persons. And their accuracies and consistencies with the analysis of receive operating characteristic(ROC)and value of Kappa were evaluated. Results Compared with the control group,the serum CRP,CA19-9 and CEA in patients with colon cancer and inflammatory bowel disease were significantly increased. The levels of CEA and CA19-9 in colon cancer group were obviously higher than those of inflammatory bowel disease group and control group. ROC was used to compare the diagnostic value of CEA,CA19-9 and CRP in discriminating benign inflammatory and colon cancer groups,indicating the diagnostic value of CRP was better than that of CEA and CA19-9. The AUC of combined detection of CEA,CA19-9 and CRP was 0. 886. Conclusion Combined detection of CEA, CA199 and CRP can help improve the diagnosis accuracy of colorectal cancer. The diagnostic accuracy was superior to individual item.
