CAJ | 학술논문

目的：探讨阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea hypopnea syndrome，OSAHS）与急性脑梗死短期预后的关系及是否存在性别差异。方法选取急性脑梗死患者85例，所有患者均行多导睡眠图检查，根据睡眠呼吸暂停指数（apnea hyponea index，AHI）将患者为分为单纯脑梗死组37例，脑梗死伴轻度 OSAHS 组23例，脑梗死伴中重度 OSAHS 组25例，对所有患者在入院及出院时行美国国立卫生研究院卒中量表（ national institute of health stoke scale，NIHSS）及 Rankin 量表（modified rankin scale，mRS）评分，比较3组神经功能缺损程度改善的情况且是否存在性别差异。结果与单纯脑梗死组相比，中重度 OSAHS 组出院时 NHISS 评分更高，出院时NIHSS 评分及 mRS 评分下降值更低，差异均有统计学意义（ P ﹤0.05）。与男性单纯脑梗死组相比，男性中重度OSAHS 组出院时 NIHSS 及 mRS 评分下降值评分下降值均更低，差异有统计学意义（P ﹤0.01或﹤0.05），在女性中未发现此种差异。结论 OSAHS 可能与男性急性脑梗死患者短期不良预后有关。
목적：탐토조새성수면호흡잠정저통기종합정（obstructive sleep apnea hypopnea syndrome，OSAHS）여급성뇌경사단기예후적관계급시부존재성별차이。방법선취급성뇌경사환자85례，소유환자균행다도수면도검사，근거수면호흡잠정지수（apnea hyponea index，AHI）장환자위분위단순뇌경사조37례，뇌경사반경도 OSAHS 조23례，뇌경사반중중도 OSAHS 조25례，대소유환자재입원급출원시행미국국립위생연구원졸중량표（ national institute of health stoke scale，NIHSS）급 Rankin 량표（modified rankin scale，mRS）평분，비교3조신경공능결손정도개선적정황차시부존재성별차이。결과여단순뇌경사조상비，중중도 OSAHS 조출원시 NHISS 평분경고，출원시NIHSS 평분급 mRS 평분하강치경저，차이균유통계학의의（ P ﹤0.05）。여남성단순뇌경사조상비，남성중중도OSAHS 조출원시 NIHSS 급 mRS 평분하강치평분하강치균경저，차이유통계학의의（P ﹤0.01혹﹤0.05），재녀성중미발현차충차이。결론 OSAHS 가능여남성급성뇌경사환자단기불량예후유관。
Objective To determine whether an association exists between obstructive sleep apnea hypopnea syndrome( OASHS)and short-term prognosis of acute cerebral infarction in different genders. Methods Patients with acute cerebral infarction(n = 85)were recruited and divided into pure cerebral infarction group(n = 37),cerebral infarction with mild OSAHS group( n = 23)and cerebral infarction with moderate to severe OSAHS group(n = 25)according to the monitoring results of apnea hyponea index(AHI). The degree of neurologic impairment was assessed by National Institutes of Health Stroke Scale(NIHSS)and modified Rankin Score(mRS)on admission and before discharge. Results The NIHSS scores before discharge,the reduced values of NIHSS and mRS in the cerebral infarction with moderate to severe OSAHS group were significantly different from those in pure cerebral infarction group (P ﹤ 0. 05). Significant difference in reduced values of NIHSS and mRS were also found in male(P ﹤0. 01 or ﹤ 0. 05),but not in female. Conclusion The severity of OASHS is related to the increased risk of poor prognosis in male patients with acute cerebral infarction.