CAJ | 학술논문

目的：研究DJ-1蛋白在卵巢癌患者血清中的表达水平及其意义。方法选取卵巢上皮性肿瘤患者52例为患者组，其中良性卵巢肿瘤9例，交界性卵巢肿瘤5例，卵巢癌38例；非卵巢肿瘤患者20例为对照组，采用双抗体夹心法测定2组患者血清中DJ-1蛋白的水平。结果对照组血清中DJ-1蛋白水平明显低于各种卵巢肿瘤患者（P<0.05）。卵巢癌患者血清DJ-1蛋白水平高于交界性卵巢肿瘤和良性卵巢肿瘤患者，交界性卵巢肿瘤高于良性卵巢肿瘤患者（P<0.05）；低分化和中分化卵巢癌患者血清DJ-1水平均高于高分化卵巢癌患者（P<0.05）；不同手术病理分期和不同组织学分类的卵巢癌患者血清DJ-1水平差别无统计学意义（P>0.05）。结论 DJ-1参与了卵巢癌的发生和发展，可作为卵巢癌诊断及预后预测的血清学指标。
목적：연구DJ-1단백재란소암환자혈청중적표체수평급기의의。방법선취란소상피성종류환자52례위환자조，기중량성란소종류9례，교계성란소종류5례，란소암38례；비란소종류환자20례위대조조，채용쌍항체협심법측정2조환자혈청중DJ-1단백적수평。결과대조조혈청중DJ-1단백수평명현저우각충란소종류환자（P<0.05）。란소암환자혈청DJ-1단백수평고우교계성란소종류화량성란소종류환자，교계성란소종류고우량성란소종류환자（P<0.05）；저분화화중분화란소암환자혈청DJ-1수평균고우고분화란소암환자（P<0.05）；불동수술병리분기화불동조직학분류적란소암환자혈청DJ-1수평차별무통계학의의（P>0.05）。결론 DJ-1삼여료란소암적발생화발전，가작위란소암진단급예후예측적혈청학지표。
Objective To investigate serum DJ-1 expression and its significance in ovarian cancer. Methods The expression levels of DJ-1 protein were detected by double antibody sandwich method in 52 cases of ovarian tumors (9 cases of benign ovarian tumors, 5 cases of borderline ovarian tumors and 38 cases of ovarian cancer,ovarian tumor group and 20 non-ovarian tumors (control group). Results The expression of DJ-1 protein was lower in the control group than that in ovarian tumor group (P<0.05). The expression of serum DJ-1 protein was higher in ovarian cancer than that in borderline ovarian tumors and in benign ovarian tumors. The expression of serum DJ-1 protein was higher in borderline ovarian tumors than that in benign ovarian tumors (P<0.05).The expression of serum DJ-1 protein was higher in poorly differentiated and moderately differentiated ovarian cancer than that in high-grade differentiated ovarian cancer (P<0.05). No significant dif-ference was found in the expression serum of DJ-1 protein between different pathological and different histological types of ovarian cancer (P>0.05). Conclusion DJ-1 might be used as a serum marker in the diagnosis of ovarian cancer. It might be involved in the pathogenesis of ovarian cancer,and could predit the development and prognosis of ovarian cancer.