天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2014年
9期
896-898,899
,共4页
肝炎,乙型,慢性%肝炎,丙型,慢性%肝%炎症%铁代谢
肝炎,乙型,慢性%肝炎,丙型,慢性%肝%炎癥%鐵代謝
간염,을형,만성%간염,병형,만성%간%염증%철대사
hepatitis B,chronic%hepatitis C,chronic%liver%inflammation%iron metabolism
目的：探讨血清铁代谢指标与病毒性肝炎肝脏炎症活动的关系，以及乙型与丙型肝炎患者血清铁代谢指标的差异。方法入组135例乙肝患者和31例丙型肝炎患者，收集患者血清铁（SI）、血清铁蛋白（SF）、转铁蛋白（TRF）、总铁结合力（TIBC）等指标，并计算转铁蛋白饱和度（TS），肝功能指标丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总胆红素（TBIL）、白蛋白（ALB）。从乙肝患者中选取与丙肝患者在年龄、性别比例、肝功能水平相匹配的39例患者，比较2组铁代谢指标水平。结果 TRF、TIBC与年龄呈负相关；SI、SF、TS分别与ALT、AST、TBIL呈正相关，SF、TS与ALB呈负相关；TRF、TIBC分别与ALT、AST、TBIL呈负相关，与ALB呈正相关（r=0.551）。丙型肝炎患者的SF高于乙型肝炎患者，TRF及TIBC低于乙型肝炎患者（均P＜0.05），SI及TS在2组中差异无统计学意义。结论血清铁代谢指标与肝脏炎症活动有显著相关性；慢性丙型肝炎与慢性乙型肝炎患者相比，铁超载现象明显。
目的：探討血清鐵代謝指標與病毒性肝炎肝髒炎癥活動的關繫，以及乙型與丙型肝炎患者血清鐵代謝指標的差異。方法入組135例乙肝患者和31例丙型肝炎患者，收集患者血清鐵（SI）、血清鐵蛋白（SF）、轉鐵蛋白（TRF）、總鐵結閤力（TIBC）等指標，併計算轉鐵蛋白飽和度（TS），肝功能指標丙氨痠轉氨酶（ALT）、天鼕氨痠轉氨酶（AST）、總膽紅素（TBIL）、白蛋白（ALB）。從乙肝患者中選取與丙肝患者在年齡、性彆比例、肝功能水平相匹配的39例患者，比較2組鐵代謝指標水平。結果 TRF、TIBC與年齡呈負相關；SI、SF、TS分彆與ALT、AST、TBIL呈正相關，SF、TS與ALB呈負相關；TRF、TIBC分彆與ALT、AST、TBIL呈負相關，與ALB呈正相關（r=0.551）。丙型肝炎患者的SF高于乙型肝炎患者，TRF及TIBC低于乙型肝炎患者（均P＜0.05），SI及TS在2組中差異無統計學意義。結論血清鐵代謝指標與肝髒炎癥活動有顯著相關性；慢性丙型肝炎與慢性乙型肝炎患者相比，鐵超載現象明顯。
목적：탐토혈청철대사지표여병독성간염간장염증활동적관계，이급을형여병형간염환자혈청철대사지표적차이。방법입조135례을간환자화31례병형간염환자，수집환자혈청철（SI）、혈청철단백（SF）、전철단백（TRF）、총철결합력（TIBC）등지표，병계산전철단백포화도（TS），간공능지표병안산전안매（ALT）、천동안산전안매（AST）、총담홍소（TBIL）、백단백（ALB）。종을간환자중선취여병간환자재년령、성별비례、간공능수평상필배적39례환자，비교2조철대사지표수평。결과 TRF、TIBC여년령정부상관；SI、SF、TS분별여ALT、AST、TBIL정정상관，SF、TS여ALB정부상관；TRF、TIBC분별여ALT、AST、TBIL정부상관，여ALB정정상관（r=0.551）。병형간염환자적SF고우을형간염환자，TRF급TIBC저우을형간염환자（균P＜0.05），SI급TS재2조중차이무통계학의의。결론혈청철대사지표여간장염증활동유현저상관성；만성병형간염여만성을형간염환자상비，철초재현상명현。
Objective To investigate the relationships between parameters of serum iron metabolism and liver in-flammatory activity grades, and to find out the difference in parameters of serum iron metabolism between patients with hepa-titis B and patients with hepatitis C. Methods A total of 166 patients with viral hepatitis were enrolled in this study, in-cluding 135 case of hepatitis B and 31 cases of hepatitis C. The serum iron metabolism indexes including serum iron (SI), se-rum ferritin (SF), transferring (TRF), total iron binding capacity (TIBC) were collected, and the transferring saturation (TS), al-anine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and albumin (ALB) were calculated. Thirty-nine patients were selected from 135 hepatitis B patients by corresponding gender, age and liver function with 31 hep-atitis C patients. The indicators of iron metabolism were compared between two groups. Results There was a positive corre-lation between age , TRF and TIBC. There were positive correlations between SI, SF, TS and ALT, AST, TBIL respectively, and negative correlations between SF, TS and ALB. TRF and TIBC were negatively correlated with ALT, AST and TBIL, but positively correlated with ALB (rs=0.551,P<0.001). The value of SF was significantly higher in patients with hepatitis C than that of patients with hepatitis B. The levels of TRF and TIBC were significantly lower in patients with hepatitis C than those of patients with hepatitis B (P<0.05). There were no significant differences in SI and TS between two groups. Conclu-sion There was a significant correlation between parameters of serum iron metabolism and live inflammatory activity grades. The iron overload phenomenon is much common in patients with chronic hepatitis C than that of patients with chronic hepatitis B.
