CAJ | 학술논문

代谢综合征（MS）、乳腺癌是女性常见疾病，三阴性乳腺癌（TNBCs）是近年来备受关注的乳腺癌的一个类型。MS的重要组分向心性肥胖、高血糖、高甘油三酯和低高密度脂蛋白胆固醇（HDL-C）增加了TNBCs的患病风险。MS的常见生物标志物胰岛素、脂联素和瘦素等在乳腺癌特别是TNBCs的发生发展中起到重要作用。胰岛素样生长因子-ⅡmRNA结合蛋白3(IMP3)是一种癌胚蛋白，可能是TNBCs浸润性癌新的生物标志物。本文对MS与TNBCs关系的研究进展进行综述。
대사종합정（MS）、유선암시녀성상견질병，삼음성유선암（TNBCs）시근년래비수관주적유선암적일개류형。MS적중요조분향심성비반、고혈당、고감유삼지화저고밀도지단백담고순（HDL-C）증가료TNBCs적환병풍험。MS적상견생물표지물이도소、지련소화수소등재유선암특별시TNBCs적발생발전중기도중요작용。이도소양생장인자-ⅡmRNA결합단백3(IMP3)시일충암배단백，가능시TNBCs침윤성암신적생물표지물。본문대MS여TNBCs관계적연구진전진행종술。
Metabolic syndrome (MS) and breast cancer are common diseases of women. Triple negative breast cancer (TNBCs) is one type of breast cancer, which is of much attention in recent years. Important components of MS include central obesity, high blood sugar, high triglycerides and low level of high-density lipoprotein (HDL-C), which increased the inci-dence risk of TNBCs. Common biomarkers of MS including insulin, adiponectin and leptin play an important role in the oc-currence and development of breast cancer, especially TNBCs. Insulin-like growth factor-IImRNA binding protein 3 (IMP3, an oncofetal protein) may be TNBCs’new invasive cancer biomarkers. In this paper, the research progress on the relation-ship between MS and TNBCs is reviewed.