生物信息学
生物信息學
생물신식학
BIOINFORMATICS
2014年
3期
218-226
,共9页
偏头痛基因%酶%KEGG pathway%DAVID%通路分析
偏頭痛基因%酶%KEGG pathway%DAVID%通路分析
편두통기인%매%KEGG pathway%DAVID%통로분석
Migraine gene%Enzyme%KEGG pathway%DAVID%Pathway analysis
搜集与偏头痛相关的编码酶的基因,利用KEGG通路分析目标基因的分布和功能,促进偏头痛遗传学研究和新药靶点研究。以“gene name” AND migraine检索PUBMED数据库,从原始文献中搜集并整理偏头痛相关酶基因数据,用DAVID在线分析工具对数据进行处理。搜索得到31个偏头痛酶基因,对7条KEGG代谢通路进行了分析:色氨酸代谢通路、酪氨酸代谢通路、精氨酸和脯氨酸代谢通路、叶酸一碳单位循环代谢通路、药物代谢通路、外源物质细胞色素P450代谢通路、肾素血管紧张素代谢通路。其中药物代谢通路包括9个药物,又以高选择性5-羟色胺重摄取抑制剂西酞普兰的应用前景最大。 DDC、DBH、MTHFD1等6个偏头痛相关基因需要完善多态性研究。 CYP450和单胺氧化酶在偏头痛的病理和治疗中都占有重要的地位。通过分析疾病相关酶基因的代谢通路,有助于了解疾病的分子病理基础,并为新药设计提供可靠靶点。
搜集與偏頭痛相關的編碼酶的基因,利用KEGG通路分析目標基因的分佈和功能,促進偏頭痛遺傳學研究和新藥靶點研究。以“gene name” AND migraine檢索PUBMED數據庫,從原始文獻中搜集併整理偏頭痛相關酶基因數據,用DAVID在線分析工具對數據進行處理。搜索得到31箇偏頭痛酶基因,對7條KEGG代謝通路進行瞭分析:色氨痠代謝通路、酪氨痠代謝通路、精氨痠和脯氨痠代謝通路、葉痠一碳單位循環代謝通路、藥物代謝通路、外源物質細胞色素P450代謝通路、腎素血管緊張素代謝通路。其中藥物代謝通路包括9箇藥物,又以高選擇性5-羥色胺重攝取抑製劑西酞普蘭的應用前景最大。 DDC、DBH、MTHFD1等6箇偏頭痛相關基因需要完善多態性研究。 CYP450和單胺氧化酶在偏頭痛的病理和治療中都佔有重要的地位。通過分析疾病相關酶基因的代謝通路,有助于瞭解疾病的分子病理基礎,併為新藥設計提供可靠靶點。
수집여편두통상관적편마매적기인,이용KEGG통로분석목표기인적분포화공능,촉진편두통유전학연구화신약파점연구。이“gene name” AND migraine검색PUBMED수거고,종원시문헌중수집병정리편두통상관매기인수거,용DAVID재선분석공구대수거진행처리。수색득도31개편두통매기인,대7조KEGG대사통로진행료분석:색안산대사통로、락안산대사통로、정안산화포안산대사통로、협산일탄단위순배대사통로、약물대사통로、외원물질세포색소P450대사통로、신소혈관긴장소대사통로。기중약물대사통로포괄9개약물,우이고선택성5-간색알중섭취억제제서태보란적응용전경최대。 DDC、DBH、MTHFD1등6개편두통상관기인수요완선다태성연구。 CYP450화단알양화매재편두통적병리화치료중도점유중요적지위。통과분석질병상관매기인적대사통로,유조우료해질병적분자병리기출,병위신약설계제공가고파점。
We collected genes encoding enzymes associated with migraine susceptibility, and did KEGG pathway analysis, to serve for migraine drug designing and genetic studying. First, we searched Pubmed using keywords“gene name” AND migraine to collect target genes from original literatures, then we used an online tool called DAVID for KEGG pathway analysis. Thirty-one genes were finally collected. Seven pathway lists were taken into analysis : Tryptophan metabolism, Tyrosine metabolism, Arginine and proline metabolism, One carbon pool by folate, Drug metabolism, Metabolism of xenobiotics by cytochrome P450, Renin-angiotensin system. Six genes ( DDC, DBH, MTHFD1, TYMS, GSTM, REN ) were claimed for further polymorphism research through our analysis. One drug Citalopram revealed a rosy prospect in migraine treatment as a high selective serotonin reuptake inhibitor. We also concluded that CYP450 and MAOA played important roles in migraine pathophysiology and treatment. Through pathway analysis of disease associated genes/enzymes,we claimed that it can help to understand the molecular basis of diseases and provide potential targets for drug development.