CAJ | 학술논문

在对两种模式生物酵母与果蝇胚胎期核小体定位进行研究时，发现不同物种间以及同一物种中不同表达模式基因上的核小体分布呈现出差显著异性。在总体上，转录起始位点附近的酵母核小体NFR区域比果蝇的NFR短。经基因中心对齐后，酵母与果蝇胚胎期沉默型基因的核小体缺失区域的两个边界中间处共同呈现了一个明确有着均匀间隔的核小体数n，且随着基因长度L的变长其周期性特性逐渐变模糊，但果蝇的图谱表现的更为复杂。结果表明，从单细胞酵母生物到多细胞果蝇生物间基因组的进化过程中，核小体组织的演化既有变异性，也具有保守性。
재대량충모식생물효모여과승배태기핵소체정위진행연구시，발현불동물충간이급동일물충중불동표체모식기인상적핵소체분포정현출차현저이성。재총체상，전록기시위점부근적효모핵소체NFR구역비과승적NFR단。경기인중심대제후，효모여과승배태기침묵형기인적핵소체결실구역적량개변계중간처공동정현료일개명학유착균균간격적핵소체수n，차수착기인장도L적변장기주기성특성축점변모호，단과승적도보표현적경위복잡。결과표명，종단세포효모생물도다세포과승생물간기인조적진화과정중，핵소체조직적연화기유변이성，야구유보수성。
By studying nucleosome positioning during embryonic period of two model organisms, Yeast and Drosophila, we found that nucleosome are differently distributed along genome-wide genes which either belong to different species or the same species in different expression patterns. In general, nucleosome free regions ( NFR) regions around the transcription start sites in yeast are narrower than that in Drosophila. If aligned by the gene center, there always are a well-defined number n of uniformly spaced nucleosomes in the middle of NFRs for embryo silence genes in both species, and the characteristics of these uniformly spaced nucleosomes gradually go fuzzy with the gene length L being longer , while drosophila presents more complexity and ambiguity than yeast relatively. The results show that the evolution of genome nucleosomes organization holds both variability and conservatism from unicellular organism to the multicellular organism.