中华实验和临床感染病杂志(电子版)
中華實驗和臨床感染病雜誌(電子版)
중화실험화림상감염병잡지(전자판)
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2014年
4期
493-495
,共3页
梁艳%张丽%马书敏%曾兆清%王磊%张立新
樑豔%張麗%馬書敏%曾兆清%王磊%張立新
량염%장려%마서민%증조청%왕뢰%장립신
猩红热%药敏试验%A组β型溶血性链球菌%济南地区
猩紅熱%藥敏試驗%A組β型溶血性鏈毬菌%濟南地區
성홍열%약민시험%A조β형용혈성련구균%제남지구
Scarlet fever%Drug sensitive test%Group Aβ-haemolytic streptococcus%Jinan area
目的:观察济南地区猩红热患者的病原菌及对目前常用抗菌药物的敏感性。方法对2011年1月至2013年6月济南市传染病医院住院的猩红热患者,进行咽拭子采集、细菌培养,细菌鉴定后采用K-B纸片扩散法进行药敏试验。结果50例猩红热患者培养出A组β型溶血性链球菌(GAS),GAS对青霉素、氨苄青霉素、头孢曲松、头孢噻肟钠、头孢呋辛、头孢唑林、头孢唑肟及万古霉素的敏感性均为100%;对左旋氧氟沙星、氧氟沙星的敏感率为94%、中介率为6%;对克林霉素的敏感率为8%、中介率为4%、耐药率为88%;对红霉素的耐药率为100%。结论山东济南地区猩红热的病原菌GAS对大环内酯类抗菌药物和克林霉素耐药率高,对青霉素类、头孢菌素类及喹诺酮类抗菌药物具有高度敏感性,青霉素类仍然是治疗猩红热的首选药物。
目的:觀察濟南地區猩紅熱患者的病原菌及對目前常用抗菌藥物的敏感性。方法對2011年1月至2013年6月濟南市傳染病醫院住院的猩紅熱患者,進行嚥拭子採集、細菌培養,細菌鑒定後採用K-B紙片擴散法進行藥敏試驗。結果50例猩紅熱患者培養齣A組β型溶血性鏈毬菌(GAS),GAS對青黴素、氨芐青黴素、頭孢麯鬆、頭孢噻肟鈉、頭孢呋辛、頭孢唑林、頭孢唑肟及萬古黴素的敏感性均為100%;對左鏇氧氟沙星、氧氟沙星的敏感率為94%、中介率為6%;對剋林黴素的敏感率為8%、中介率為4%、耐藥率為88%;對紅黴素的耐藥率為100%。結論山東濟南地區猩紅熱的病原菌GAS對大環內酯類抗菌藥物和剋林黴素耐藥率高,對青黴素類、頭孢菌素類及喹諾酮類抗菌藥物具有高度敏感性,青黴素類仍然是治療猩紅熱的首選藥物。
목적:관찰제남지구성홍열환자적병원균급대목전상용항균약물적민감성。방법대2011년1월지2013년6월제남시전염병의원주원적성홍열환자,진행인식자채집、세균배양,세균감정후채용K-B지편확산법진행약민시험。결과50례성홍열환자배양출A조β형용혈성련구균(GAS),GAS대청매소、안변청매소、두포곡송、두포새우납、두포부신、두포서림、두포서우급만고매소적민감성균위100%;대좌선양불사성、양불사성적민감솔위94%、중개솔위6%;대극림매소적민감솔위8%、중개솔위4%、내약솔위88%;대홍매소적내약솔위100%。결론산동제남지구성홍열적병원균GAS대대배내지류항균약물화극림매소내약솔고,대청매소류、두포균소류급규낙동류항균약물구유고도민감성,청매소류잉연시치료성홍열적수선약물。
Objective To investigate pathogenic bacteria causing scarlet fever and its sensibility to common antibacterial drugs in Jinan of Shandong Province. Methods Scarlet fever patients hospitalized in Jinan Infectious Diseases Hospital from January 2011 to July 2013 were collected, restrospectively. Collection and cultivation of throat swabs were done in these patiens and then drug sensitive tests were proceeded by K-B paper slip diffusion method. Results Group Aβ-haemolytic streptococcus (GAS) were cultivated in 50 patients with scarlet fever. The sensibility rate of GAS to penicillin, ampicillin, ceftriaxone, cefotaxime sodium, cefuroxime, cefazolin, ceftizoxime and vancomycin were all 100%. The sensibility rate, mesomerism rate and resistant rate of GAS to levolfoxacin and olfoxacin were 94%, 6%and 0%, respectively. The sensibility rate, mesomerism rate and resistant rate of GAS to clindamycin was 8%, 4% and 88%, respectively. The resistant rate of GAS to erythromycin was 100%. Conclusions Pathogenic bacteria GAS of scarlet fever patients in Jinan of Shandong Province has high resistance to macrocyclic lactone antibiotics and has high sensibility to penicillins, cephem antibiotics and quinolone antibacterials. Penicillins are still choice drugs in treating scarlet fever.