CAJ | 학술논문

目的：观察使用干扰素治疗的慢性丙型肝炎（HCV）患者出现视网膜病变的特征。方法接受干扰素治疗后出现视网膜病变的患者共24例纳入研究。所有患者均进行矫正视力、裂隙灯显微镜、散瞳间接检眼镜、眼底彩色照相检查。眼底检查由具有丰富经验的眼底病医生完成。观察所有患者的眼底病变特征。结果本研究24例患者中男性16例，女性8例，男女比例为2︰1；年龄21～78岁，平均年龄（48±14）岁。24例患者中有35只眼眼底异常，双眼发病13例，单眼发病11例。12例患者使用后出现视物模糊。眼底检查中：35只患眼中17例23只眼，占患眼的65.7%；眼底表现为单纯棉绒斑，单纯视网膜出血2例2只眼，占患眼的5.7%；棉绒斑合并视网膜出血8例10只眼，占患眼的28.6%。棉绒斑及出血多位于视盘旁颞上或颞下血管附近，少数可散布于全后极部血管旁；其出血部位多位于棉绒斑旁，表现为后极部火焰状、点状出血或Roth斑。结论干扰素所致眼底视网膜病变最常见的特征为棉绒斑，使用后建议定期随访。
목적：관찰사용간우소치료적만성병형간염（HCV）환자출현시망막병변적특정。방법접수간우소치료후출현시망막병변적환자공24례납입연구。소유환자균진행교정시력、렬극등현미경、산동간접검안경、안저채색조상검사。안저검사유구유봉부경험적안저병의생완성。관찰소유환자적안저병변특정。결과본연구24례환자중남성16례，녀성8례，남녀비례위2︰1；년령21～78세，평균년령（48±14）세。24례환자중유35지안안저이상，쌍안발병13례，단안발병11례。12례환자사용후출현시물모호。안저검사중：35지환안중17례23지안，점환안적65.7%；안저표현위단순면융반，단순시망막출혈2례2지안，점환안적5.7%；면융반합병시망막출혈8례10지안，점환안적28.6%。면융반급출혈다위우시반방섭상혹섭하혈관부근，소수가산포우전후겁부혈관방；기출혈부위다위우면융반방，표현위후겁부화염상、점상출혈혹Roth반。결론간우소소치안저시망막병변최상견적특정위면융반，사용후건의정기수방。
Objective To observe and analyze the retinopathy associated with interferon therapy in patients with chronic hepatitis C (CHC). Methods Twenty-four CHC patients (including 16 men and 8 women) with retinopathy were collected. The detailed ocular examinations including corrected visual acuity, intraocular pressure, slit lamp microscope, indirect ophthalmoscope and color fundus photography were done in 24 patients. Fundus examinations were carried out by experienced ocular fundus doctors and the retinopathy characteristics were recorded. Results The age of the patients varied from 21 to 78 years, with the average of 48 ± 14 years old. Total of 35 eyes were found with retinopathy in 24 patients among which 13 patients were found with bilateral retinopathy and 11 patients with unilateral retinopathy. Blurred vision were found in 12 patients. Cotton-wool spots (CWS) without retinal hemorrhage, mostly located close to temporal peripapillary vessels, were found in 23 eyes (65.7%) of 17 patients. Two eyes (5.7%) of 2 cases were found to have lfaming or spotting hemorrhage located in posterior pole. Ten eyes (28.6%) of 8 cases were found to have retinal hemorrhage mostly located near CWS. Conclusions CWS are the most common ocular lesions in retinopathy associated with interferon therapy in patients with CHC. The patients should be followed up after treatment.