中华口腔医学研究杂志（电子版）
中華口腔醫學研究雜誌（電子版）
중화구강의학연구잡지（전자판）
CHINESE JOURNAL OF STOMATOLOGICAL RESEARCH(ELECTRONIC VERSION)
2014年
4期
274-280
,共7页
粪肠球菌%难治性根尖周炎%相关性%Meta分析
糞腸毬菌%難治性根尖週炎%相關性%Meta分析
분장구균%난치성근첨주염%상관성%Meta분석
Enterococcus faecalis%Refractory periapical periodontitis%Correlation%Meta-analysis
目的系统评价粪肠球菌和难治性根尖周炎之间的相关性。方法计算机检索PubMed、ScienceDirect、EMbase、万方数据、CNKI、维普等数据库，全面收集有关难治性根尖周炎中粪肠球菌检出率的独立队列研究、病例-对照研究以及横断面研究，并追溯所获文献的参考文献，检索时限均从建库至2013年12月。按纳入和排除标准筛选文献、提取资料和评价质量后，采用Stata 12.0软件进行统计分析。结果最终纳入18项研究，共728例难治性根尖周炎病例和748例对照病例。 Meta分析结果显示，难治性根尖周炎中粪肠球菌的检出率明显高于对照病例，差异有统计学意义[OR＝3.559，95％ CI（1.696，7.470），P＜0.05]。亚组分析和敏感性分析结果与上述结果一致。结论粪肠球菌与难治性根尖周炎间存在较为密切的关联，但具体机制仍待进一步研究。受纳入研究质量和数量所限，上述结论尚需今后开展更多高质量的研究加以验证和更新。
目的繫統評價糞腸毬菌和難治性根尖週炎之間的相關性。方法計算機檢索PubMed、ScienceDirect、EMbase、萬方數據、CNKI、維普等數據庫，全麵收集有關難治性根尖週炎中糞腸毬菌檢齣率的獨立隊列研究、病例-對照研究以及橫斷麵研究，併追溯所穫文獻的參攷文獻，檢索時限均從建庫至2013年12月。按納入和排除標準篩選文獻、提取資料和評價質量後，採用Stata 12.0軟件進行統計分析。結果最終納入18項研究，共728例難治性根尖週炎病例和748例對照病例。 Meta分析結果顯示，難治性根尖週炎中糞腸毬菌的檢齣率明顯高于對照病例，差異有統計學意義[OR＝3.559，95％ CI（1.696，7.470），P＜0.05]。亞組分析和敏感性分析結果與上述結果一緻。結論糞腸毬菌與難治性根尖週炎間存在較為密切的關聯，但具體機製仍待進一步研究。受納入研究質量和數量所限，上述結論尚需今後開展更多高質量的研究加以驗證和更新。
목적계통평개분장구균화난치성근첨주염지간적상관성。방법계산궤검색PubMed、ScienceDirect、EMbase、만방수거、CNKI、유보등수거고，전면수집유관난치성근첨주염중분장구균검출솔적독립대렬연구、병례-대조연구이급횡단면연구，병추소소획문헌적삼고문헌，검색시한균종건고지2013년12월。안납입화배제표준사선문헌、제취자료화평개질량후，채용Stata 12.0연건진행통계분석。결과최종납입18항연구，공728례난치성근첨주염병례화748례대조병례。 Meta분석결과현시，난치성근첨주염중분장구균적검출솔명현고우대조병례，차이유통계학의의[OR＝3.559，95％ CI（1.696，7.470），P＜0.05]。아조분석화민감성분석결과여상술결과일치。결론분장구균여난치성근첨주염간존재교위밀절적관련，단구체궤제잉대진일보연구。수납입연구질량화수량소한，상술결론상수금후개전경다고질량적연구가이험증화경신。
Objective To evaluate the correlation between Enterococcus faecalis and refractory periapical periodontitis. Methods Databases including PubMed, ScienceDirect, EMbase, WanFang Data, CNKI and VIP were searched from inception to December, 2013, so as to identify the independent cohort studies, case-control studies and cross-sectional studies. Moreover, the references of relevant studies were retrieved. According to the inclusion and exclusion criteria, the studies were screened, the data was extracted, and the methodological quality of the included studies was assessed. Then Meta-analysis was performed by Stata 12.0 software. Results A total of 18 studies were included, including 728 rafractory periapical periodontitis cases and 748 controlled cases . The results of Meta-analysis showed that the refractory periapical periodontitis group was more likely to have Enterococcus faecalis infection than the control group [OR=3.559, 95% CI(1.696,7.470), P<0.05]. The same results were found in both sub-group and sensitivity analysis . Conclusions Enterococcus faecalis is closely related to refractory periapical periodontitis. However, detailed pathogenesis mechanism is still unknown. Due to the limited quality and quantity of the included studies , more high-quality studies are required to prove the analysis results above.
