CAJ | 학술논문

目的：探讨涎腺腺泡细胞癌的临床病理学特征和预后相关因素。方法回顾性分析5例涎腺腺泡细胞癌的临床资料、组织学形态和免疫表型，并复习相关文献。结果男1例，女4例。肿瘤位于口腔牙龈1例，腮腺4例。临床表现为生长缓慢无痛性肿块4例，另1例肿瘤近期生长迅速，偶有疼痛。镜下观察：组织学形态4例呈乳头囊状型，肿瘤细胞形态温和；1例实性伴微囊型肿瘤浸润性生长伴点灶状坏死，肿瘤细胞异形明显，呈高级别转化形态。免疫组化染色示 CK 阳性，P63、SMA 阴性；Ki-67阳性指数4例﹤5%，1例高级别患者为30%。4例随访13~78个月，未见肿瘤复发和转移；1例高级别患者术后10个月死亡。结论腺泡细胞癌好发于女性腮腺，通常为低度恶性，而高级别转化腺泡细胞癌预后差，其临床综合治疗尚须进一步探讨。
목적：탐토연선선포세포암적림상병이학특정화예후상관인소。방법회고성분석5례연선선포세포암적림상자료、조직학형태화면역표형，병복습상관문헌。결과남1례，녀4례。종류위우구강아간1례，시선4례。림상표현위생장완만무통성종괴4례，령1례종류근기생장신속，우유동통。경하관찰：조직학형태4례정유두낭상형，종류세포형태온화；1례실성반미낭형종류침윤성생장반점조상배사，종류세포이형명현，정고급별전화형태。면역조화염색시 CK 양성，P63、SMA 음성；Ki-67양성지수4례﹤5%，1례고급별환자위30%。4례수방13~78개월，미견종류복발화전이；1례고급별환자술후10개월사망。결론선포세포암호발우녀성시선，통상위저도악성，이고급별전화선포세포암예후차，기림상종합치료상수진일보탐토。
Objective To investigate the clinico-pathological characteristics and prognostic factors of acinic cell carcinoma(AciCC). Methods Five cases diagnosed AciCC were investigated with clinical date,histology and immunohistochemistry. The literatures were reviewed. Results Among 5 cases,4 cases were females and 1 case was male. The lesions were involved in parotid 4 cases,and oral gingival 1 case. 4 patients showed slow-growing painless mass and one patient complained the tumor rapid grow in recent,occasional pain. Microscopi-cally,4 cases represented papillary cystic type and the neoplastic cells were moderate. Necrosis was present in one case of high-grade AciCC. The neoplastic cells were positive for CK but negative for P63 and SMA. The Ki-67 index was low( ﹤ 5% )in 4 cases,while it was high(30% )in the high-grade compoent. 4 cases were fol-lowed up for 13-78 months,and recurrence and metastasis were not found. The patient of high-grade AciCC died 10 months after operated. Conclusions AciCC often occurs predominantly in parotid of female. Most of AciCCs are low-grade. However,the patients of high-grade AciCC need further explore about comprehensive clinical treatment and closely followed up.