CAJ | 학술논문

目的：探讨烟酰胺磷酸核糖基转移酶（Nampt）在乳腺癌组织中的表达并确定其与临床病理特征之间的关系及对患者预后的影响。方法采用免疫组化法分析83例乳腺癌患者的癌组织和癌旁正常乳腺组织中 Nampt 的表达情况。Nampt 表达与临床病理变量间的关系采用χ2检验；Nampt 对总生存率的预后价值采用 Kaplan-Meier 法评价。结果 Nampt 在乳腺癌组织中表达升高，其表达程度与肿瘤大小、淋巴结转移及 TNM 分期相关；在雌激素受体（ ER）和孕激素受体（ PR）表达阴性的癌组织中Nampt 表达更高；Nampt 高表达与较低的无病生存率及总生存率相关。结论乳腺癌组织中高表达的Nampt 与更多的恶性肿瘤生物学行为及不良预后相关。
목적：탐토연선알린산핵당기전이매（Nampt）재유선암조직중적표체병학정기여림상병리특정지간적관계급대환자예후적영향。방법채용면역조화법분석83례유선암환자적암조직화암방정상유선조직중 Nampt 적표체정황。Nampt 표체여림상병리변량간적관계채용χ2검험；Nampt 대총생존솔적예후개치채용 Kaplan-Meier 법평개。결과 Nampt 재유선암조직중표체승고，기표체정도여종류대소、림파결전이급 TNM 분기상관；재자격소수체（ ER）화잉격소수체（ PR）표체음성적암조직중Nampt 표체경고；Nampt 고표체여교저적무병생존솔급총생존솔상관。결론유선암조직중고표체적Nampt 여경다적악성종류생물학행위급불량예후상관。
Objective To study the expression of nicotinamide phosphoribosyl transferase( Nampt)in breast cancer and investigate their correlations to clinicopathological features and prognostic significance. Meth-ods The proteins of Nampt in 83 breast cancer specimens and corresponding normal breast tissue specimens were detected by immunohistochemistry. Nampt expression was correlated with clinico-pathological variables u-sing the Chi-square test. The prognostic value of visfatin for overall survival was evaluated by Kaplan-Meier esti-mates. Results Nampt in breast cancer was significantly higher than that in normal breast tissue;the expres-sion of Nampt was correlated to tumor size,lymph node metastasis,clinical TNM stage,estrogen receptor(ER) negativity,and progesterone receptor(PR)negativity. High Nampt expression was associated with poor disease-free survival and overall survival. Conclusions The expression of Nampt is positively correlated with more ma-lignant cancer behavior as well as poor patient survival in breast cancer.