中国药物评价
中國藥物評價
중국약물평개
Chinese Journal of Drug Evaluation
2014年
4期
215-217,220
,共4页
叶云%张士勇%王刚斌%程军
葉雲%張士勇%王剛斌%程軍
협운%장사용%왕강빈%정군
细菌耐药%抗菌药物%用药频度
細菌耐藥%抗菌藥物%用藥頻度
세균내약%항균약물%용약빈도
Bacterial drug resistance%Antibiotics%Defined daily doses
目的:统计分析我院2011~2013年抗菌药物使用情况及革兰阴性细菌耐药率,为临床降低细菌耐药性和合理使用抗菌药物提供参考依据。方法:采用回顾性调查方法对2011~2013年送检病原菌培养结果、同期各类别抗菌药物累计使用频度和细菌耐药率情况进行统计分析。结果:2011~2013年排名前5位的革兰阴性病原菌均为大肠埃希菌、鲍曼不动杆菌、铜绿假单胞菌、肺炎克雷伯菌及阴沟肠杆菌,每年所占比例无明显变化。抗菌药物总用药频度( DDDs )逐年减少,从2011年的255456.37 DDDs下降到2013年的155024.25 DDDs,头孢菌素+酶抑制剂类及大环内酯类用量排名逐年升高,三四代头孢菌素及喹诺酮类用量排名则逐年减少,抗真菌类及碳青霉烯类排名无明显变化。各类细菌对阿莫西林耐药率均较高,2013年基本达到100%,鲍曼不动杆菌及铜绿假单胞菌对哌拉西林他唑巴坦耐药率逐年上升,鲍曼不动杆菌对β-内酰胺类抗菌药物呈逐渐耐药趋势。结论:我院的抗菌药物使用频度呈逐年下降的趋势,而部分细菌的耐药率有增加的趋势,需要更加合理使用抗菌药物,以减缓目前的耐药形势。
目的:統計分析我院2011~2013年抗菌藥物使用情況及革蘭陰性細菌耐藥率,為臨床降低細菌耐藥性和閤理使用抗菌藥物提供參攷依據。方法:採用迴顧性調查方法對2011~2013年送檢病原菌培養結果、同期各類彆抗菌藥物纍計使用頻度和細菌耐藥率情況進行統計分析。結果:2011~2013年排名前5位的革蘭陰性病原菌均為大腸埃希菌、鮑曼不動桿菌、銅綠假單胞菌、肺炎剋雷伯菌及陰溝腸桿菌,每年所佔比例無明顯變化。抗菌藥物總用藥頻度( DDDs )逐年減少,從2011年的255456.37 DDDs下降到2013年的155024.25 DDDs,頭孢菌素+酶抑製劑類及大環內酯類用量排名逐年升高,三四代頭孢菌素及喹諾酮類用量排名則逐年減少,抗真菌類及碳青黴烯類排名無明顯變化。各類細菌對阿莫西林耐藥率均較高,2013年基本達到100%,鮑曼不動桿菌及銅綠假單胞菌對哌拉西林他唑巴坦耐藥率逐年上升,鮑曼不動桿菌對β-內酰胺類抗菌藥物呈逐漸耐藥趨勢。結論:我院的抗菌藥物使用頻度呈逐年下降的趨勢,而部分細菌的耐藥率有增加的趨勢,需要更加閤理使用抗菌藥物,以減緩目前的耐藥形勢。
목적:통계분석아원2011~2013년항균약물사용정황급혁란음성세균내약솔,위림상강저세균내약성화합리사용항균약물제공삼고의거。방법:채용회고성조사방법대2011~2013년송검병원균배양결과、동기각유별항균약물루계사용빈도화세균내약솔정황진행통계분석。결과:2011~2013년배명전5위적혁란음성병원균균위대장애희균、포만불동간균、동록가단포균、폐염극뢰백균급음구장간균,매년소점비례무명현변화。항균약물총용약빈도( DDDs )축년감소,종2011년적255456.37 DDDs하강도2013년적155024.25 DDDs,두포균소+매억제제류급대배내지류용량배명축년승고,삼사대두포균소급규낙동류용량배명칙축년감소,항진균류급탄청매희류배명무명현변화。각류세균대아막서림내약솔균교고,2013년기본체도100%,포만불동간균급동록가단포균대고랍서림타서파탄내약솔축년상승,포만불동간균대β-내선알류항균약물정축점내약추세。결론:아원적항균약물사용빈도정축년하강적추세,이부분세균적내약솔유증가적추세,수요경가합리사용항균약물,이감완목전적내약형세。
Objective:To statistic and analyze utilization of antibiotic drugs and resistance rate of gram negative bacteria in a hospital during 2011~2013 , to reduce bacterial resistance and to provide references for clinical rational use of antimicrobial drugs .Methods:Retrospective investigation method was used to statistically analyze the pathogenic bacteria culture results , antimicrobial cumulative fre-quency of each categories and results of drug resistance test.Results:Ranked the top five gram negative pathogens in 2011~2013 year were Escherichia coli,Bauman Acinetobacter,Pseudomonas aeruginosa,Klebsiella pneumoniae and Enterobacter cloacae , the proportion has no obvious changed in each year.The total DDDs of antibacterial drugs reduced year by year , down from 255456.37 DDDs in 2011 to 155024.25 DDDs in 2013 , cephalosporin and enzyme inhibitors and macrolide consumption ranked increased year by year , the three or four generation cephalosporins and quinolones such amount was reduced year by year , antifungal fungi and carbapenem ranking had no obvious changed.All kinds of bacteria were high resistant to amoxicillin , reached 100% in 2013 , Bauman Acinetobacter and Pseudo-monas aeruginosa to piperacillin tazobactam resistant rate increased year by year , Bauman Acinetobacter to beta lactam antibiotics drugs showed a gradual trend of drug resistance.Conclusion:The frequency of antimicrobial drug use showed a declining trend in our hospital , and drug-resistant bacteria rate increased , in order to reduce the resistance present form ,we need to more rational use antimicrobial a-gents.