CAJ | 학술논문

目的：研究非霍奇金淋巴瘤（NHL）组织中M2型巨噬细胞和调节性T细胞含量与临床特点的关系。方法：对84例经临床及病理确诊的NHL患者采用免疫组化法检测Foxp3和CD163在NHL肿瘤组织中的表达情况，分析Foxp3和CD163阳性细胞绝对数和NHL分期、乳酸脱氢酶水平、是否结外受侵和国际预后指数（IPI）之间的关系。结果：Foxp3和CD163阳性细胞绝对数升高与不同的NHL分期、乳酸脱氢酶水平、是否结外受侵和IPI之间有关。结论：临床上可以通过联合检测NHL患者病理组织中Foxp3和CD163水平监测疾病的发展状况。
목적：연구비곽기금림파류（NHL）조직중M2형거서세포화조절성T세포함량여림상특점적관계。방법：대84례경림상급병리학진적NHL환자채용면역조화법검측Foxp3화CD163재NHL종류조직중적표체정황，분석Foxp3화CD163양성세포절대수화NHL분기、유산탈경매수평、시부결외수침화국제예후지수（IPI）지간적관계。결과：Foxp3화CD163양성세포절대수승고여불동적NHL분기、유산탈경매수평、시부결외수침화IPI지간유관。결론：림상상가이통과연합검측NHL환자병리조직중Foxp3화CD163수평감측질병적발전상황。
Objective :To study the Non-Hodgkin's lymphoma(NHL) in the organization type M2 macro-phages and regulatory T cells in relationship with the prognosis of patients .Methods:A retrospective analysis of 84 patients with NHL pathologic ,clinical and follow-up data ,using the immunohistochemical method ,to detect ex-pression of Foxp3 and CD163 in NHL tumor tissue .The absolute analysis Foxp3 positive cells and NHL stage and lac-tate dehydrogenase levels ,whether outside invaded the relationship between the international prognostic index .Re-sults :The absolute levels and different NHL Foxp3 and CD163 positive cells in installment ,lactate dehydrogenase levels ,whether "invaded and international prognostic index between the outside .Foxp3 and CD163 high expression of patients with NHL stage (P <0 .05) ,lactate dehydrogenase levels (P <0 .05) ,whether the knot invaded (P <0 . 05) and the international prognostic index (P <0 .05) .Conclusion:Clinical can through joint detection Foxp3 and CD163 levels in patients with NHL histopathologic evaluation of the prognosis of patients .