CAJ | 학술논문

探讨Ⅱ型糖尿病患者轻度认知功能障碍（ MCI）的相关危险因素．将165例Ⅱ型糖尿病患者根据MoCA北京版量表分为Ⅱ型糖尿病认知功能障碍组95例及Ⅱ型糖尿病认知功能正常组70例，比较两组的临床资料，进行非条件Logistic回归分析认知功能障碍的相关危险因素．与对照组比较，MCI组较对照组糖尿病病程长（P＜0．05）， HbA1c、空腹胰岛素水平、TC、LDL-C水平、同型半胱氨酸水平、尿微量白蛋白明显高于对照组（P＜0．05）；两组间BMI、空腹血糖、餐后2 h血糖、TG、HDL-C、肌酐、血尿酸、收缩压、舒张压间差异无统计学意义．非条件Logistic回归分析结果显示高龄、血糖控制不佳、糖尿病病程长、高血压病史、糖尿病肾病、糖尿病周围神经病变均是Ⅱ型DM合并认知功能障碍的独立危险因素．早期诊断有助于预防和减少认知功能障碍的发生．
탐토Ⅱ형당뇨병환자경도인지공능장애（ MCI）적상관위험인소．장165례Ⅱ형당뇨병환자근거MoCA북경판량표분위Ⅱ형당뇨병인지공능장애조95례급Ⅱ형당뇨병인지공능정상조70례，비교량조적림상자료，진행비조건Logistic회귀분석인지공능장애적상관위험인소．여대조조비교，MCI조교대조조당뇨병병정장（P＜0．05）， HbA1c、공복이도소수평、TC、LDL-C수평、동형반광안산수평、뇨미량백단백명현고우대조조（P＜0．05）；량조간BMI、공복혈당、찬후2 h혈당、TG、HDL-C、기항、혈뇨산、수축압、서장압간차이무통계학의의．비조건Logistic회귀분석결과현시고령、혈당공제불가、당뇨병병정장、고혈압병사、당뇨병신병、당뇨병주위신경병변균시Ⅱ형DM합병인지공능장애적독립위험인소．조기진단유조우예방화감소인지공능장애적발생．
To investigate the risk factors of mild cognitive impairment ( MCI) in patients with type Ⅱdiabetes (T2 DM), a total of 165 T2DM patients were divided into T2DM with MCI group (n=95) and T2DM with normal cognitive function (NMCI) group (n=70).Montre-al cognitive assessment scale ( MoCA) was used to assess the functional status in two groups of patients .Non condition logstic regression was used to analyze the related factors of cogni -tive dysfunction .Compared with the control group , the diabetes course , blood levels of HbAIc , fasting insulin , total cholesterol , low-density lipoprotein-cholesterol , homocysteic acid, and micro urine protein significantly increased .There were no significant differences in BMI, fasting blood glucose, postprandial 2 h blood sugar, triglycerides, high density lipo-protein-cholesterol , creatinine , blood uric acid , contractive pressure , and diastolic blood pressure between the two groups .Multiple regression analysis showed that older age , ineffi-cient control of blood glucose , long duration of diabetes mellitus , history of hypertension , di-abetic nephropathy , and diabetic perineuropathy were significantly independent determinant for the T2DM with cognitive dysfunction.Many risk factors may play a part in T2DM with MCI.Early detection and prompting medical attention may help prevent and decrease the prevalence of MCI in patients with T 2DM.