CAJ | 학술논문

研究虎眼万年青乙醇提取物体内抗氧化性的作用．利用加热回流提取方法提取虎眼万年青总皂苷，分别以高中低（30、15、7．5 mg/kg）三种不同剂量的虎眼万年青乙醇提取物，对小鼠灌胃给药14 d，并以Vc 和水分别作阳性对照和阴性对照．通过测定小鼠血清和肝组织中的超氧化歧化酶（ SOD）和丙二醛（ MDA）值来研究虎眼万年青乙醇提取物体内抗氧化活性．结果表明，与阴性对照（蒸馏水）相比，虎眼万年青乙醇提取物能明显提高小鼠血清和肝组织中SOD的活力，降低MDA的含量（ P＜0．01）；与阳性对照Vc相比，高剂量组血清中SOD的活力显著高于对照组（P＜0．01），且肝组织中MDA的含量显著低于对照组（P＜0．05）．虎眼万年青乙醇提取物具有较强的体内抗氧化活性．
연구호안만년청을순제취물체내항양화성적작용．이용가열회류제취방법제취호안만년청총조감，분별이고중저（30、15、7．5 mg/kg）삼충불동제량적호안만년청을순제취물，대소서관위급약14 d，병이Vc 화수분별작양성대조화음성대조．통과측정소서혈청화간조직중적초양화기화매（ SOD）화병이철（ MDA）치래연구호안만년청을순제취물체내항양화활성．결과표명，여음성대조（증류수）상비，호안만년청을순제취물능명현제고소서혈청화간조직중SOD적활력，강저MDA적함량（ P＜0．01）；여양성대조Vc상비，고제량조혈청중SOD적활력현저고우대조조（P＜0．01），차간조직중MDA적함량현저저우대조조（P＜0．05）．호안만년청을순제취물구유교강적체내항양화활성．
To study the antioxidant effect of ethanol extract of Ornithogalum caudatum Ait in vivo, total saponins of Ornithogalum caudatum Ait was extracted by heat reflux extraction . ethanol extracts of three different doses (30,15,7.5mg/kg) feed mice for 14 days.Vc solu-tion and water were used as positive control and negative control .Detecting numerical chan-ges of the mice serum, liver tissue of malondialdehyde ( MDA) and super oxide dismutase ( SOD) , experimental data was used to analyze and study the tiger yield of ethanol extracts of antioxidant activity in the body .The results showed that compared with negative control ( dis-tilled water ) , ethanol extract of Ornithogalum caudatum Ait could increase serum and liver tissue SOD, decrease MDA content (P <0.01).Compared with the positive control Vc group, a higher concentration of SOD in serum (P <0.05) and MDA in liver tissue (P <0.05) was detected in high dose group (30 mg/kg) .The results showed that the ethanol ex-tract of Ornithogalum caudatum Ait showed good antioxidant activity .