CAJ | 학술논문

为研究丁香苦苷PLGA纳米粒（ SYR-NP）的体外释药规律，采用动态透析技术考察SYR-NP体外释药性能，并用高效液相测定SYR-NP和SYR溶液的含量，以累积释药百分率进行不同模型的拟合．SYR-NP的体外释放规律基本符合Higuchi方程的释药模型，拟合的释药动力学方程为 Q＝0．1281＋0．0189t1/2（r＝0．9568）．相比于药物溶液，SYR-NP具有良好的缓释的作用．
위연구정향고감PLGA납미립（ SYR-NP）적체외석약규률，채용동태투석기술고찰SYR-NP체외석약성능，병용고효액상측정SYR-NP화SYR용액적함량，이루적석약백분솔진행불동모형적의합．SYR-NP적체외석방규률기본부합Higuchi방정적석약모형，의합적석약동역학방정위 Q＝0．1281＋0．0189t1/2（r＝0．9568）．상비우약물용액，SYR-NP구유량호적완석적작용．
In order to study the vitro release profile of Syringopicroside PLGA nanoparticles , the dynamic dialysis technology was employed to study the in vitro release ability of SYR -NP and Syringopicroside solution .The content of Syringopicroside was determined by HPLC , and the fitting of different models were performed based on the accumulative drug release percentages .The release curve of Syringopicroside PLGA nanoparticles was in line with Higuchi equation , Q=0.128 1+0.018 9t1/2 ( r=0.956 8) .Compared with the Syringopi-croside solution , SYR-NP has a satisfactory sustained release effect .