CAJ | 학술논문

目的：研究糖皮质激素短期治疗对AECOPD患者清晨空腹皮质醇的影响。方法选取38例AECOPD患者随机分为糖皮质激素组(简称激素组)和对照组(非激素组)，检测和比较治疗前后患者血清空腹皮质醇值。结果治疗后血清空腹皮质醇水平在激素组与对照组两组间比较，差异无统计学意义( P>0．05)。表明经糖皮质激素短期治疗后，对AECOPD患者血清皮质醇无明显影响。结论短期小剂量糖皮质激素干预AECOPD患者对下丘脑-垂体肾上-腺皮质( HPA)轴无显著不良影响，为其安全性提供了更多依据。
목적：연구당피질격소단기치료대AECOPD환자청신공복피질순적영향。방법선취38례AECOPD환자수궤분위당피질격소조(간칭격소조)화대조조(비격소조)，검측화비교치료전후환자혈청공복피질순치。결과치료후혈청공복피질순수평재격소조여대조조량조간비교，차이무통계학의의( P>0．05)。표명경당피질격소단기치료후，대AECOPD환자혈청피질순무명현영향。결론단기소제량당피질격소간예AECOPD환자대하구뇌-수체신상-선피질( HPA)축무현저불량영향，위기안전성제공료경다의거。
Objective To explore the effects of the short-term therapy with glucocorticoid on morning basal cortisol levels in patients with acute exacerbation chronic obstructive pulmonary disease( AECOPD) . Methods 38 patients with AECOPD were randomly divided into glucocorticoid group and control group, of which each got 19 patients for this study . The levels of basal cor-tisol levels in serum were tested and compared by radioimmunoassay before and after the treatment. Results There were no signif-icant differences between two groups in cortisol,so these two groups were comparable. Serum cortisol were reduced in both groups after treatment,However, there were no statistically significant differences between the glucocorticoid group and the control group in basal cortisol(P>0. 05). Conclusion The short-term treatment with glucocorticoid had no significant differences on the serum level of basal cortisol between the glucocorticoid group and the control group. The study suggests that short-term treatment with glu-cocorticoid had no effects on hypothalamic pituitary adrenalcortex( HPA) , so it is safe in the treatment of AECOPD.